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首页> 外文期刊>Diabetes, obesity & metabolism >Effect of cogent db, a herbal drug, on plasma insulin and hepatic enzymes of glucose metabolism in experimental diabetes.
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Effect of cogent db, a herbal drug, on plasma insulin and hepatic enzymes of glucose metabolism in experimental diabetes.

机译：一种草药，一种草药，一种草药，对实验性糖尿病在葡萄糖代谢的血浆胰岛素和肝酶的影响。

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AIMS: The present study was designed to investigate the effect of cogent db, a polyherbal drug on blood glucose, plasma insulin and the activities of hepatic glucose metabolic enzymes in alloxan-induced diabetic rats. METHODS: Male Wistar rats body weight of 180-200 g (six normal and 18 diabetic rats) were used in this study. The rats were divided into four groups after the induction of alloxan diabetes. In the experiment, six rats were used in each group: Group 1, normal rats given 2 ml of saline; Group 2, diabetic control rats given 2 ml of saline; Group 3, diabetic rats given aqueous solution of cogent db (0.45 g/body kg weight); and Group 4, diabetic rats given aqueous solution of glibenclamide (600 micro g/kg body weight). The treatment was given for 40 days. After the treatment, fasting blood glucose, plasma insulin, urine sugar and the activities of hepatic glucose metabolic enzymes were determined in normal and experimental animals. RESULTS: Treatment with cogent db resulted in a significant reduction in blood glucose and the activities of glucose-6-phosphatase and fructose-1,6-bisphosphatase in the liver, whereas the level of plasma insulin and hepatic hexokinase activity were significantly increased in alloxan-diabetic rats. CONCLUSIONS: The present investigation suggests that cogent db controls the blood glucose level by increasing glycolysis and decreasing gluconeogenesis with a lower demand of pancreatic insulin than in untreated rats. This is possible because it regulates the activities of hepatic glucose metabolic enzymes.
机译：目的：目前的研究旨在探讨Cogent DB，一种聚氯乙烯药物对血糖，血浆胰岛素以及肝葡萄糖代谢酶在阿仑胍诱导的糖尿病大鼠中的活性的影响。方法：本研究使用雄性Wistar大鼠体重180-200g（六种正常和18只糖尿病大鼠）。在诱导阿萨麻糖尿病后，大鼠分为四组。在实验中，在每组中使用六只大鼠：1组给予2ml盐水的正常大鼠;第2组，糖尿病对照大鼠给予2毫升盐水;第3组，糖尿病大鼠给出了伴有伴随的DB水溶液（0.45g /体kg重量）;和第4组，糖尿病大鼠给予Glibenclamide的水溶液（600微克/ kg体重）。治疗得到40天。在治疗后，在正常和实验动物中测定空腹血糖，血浆胰岛素，尿糖和肝葡萄糖代谢酶的活性。结果：肝脏DB的治疗导致血糖的显着降低和血糖-6-磷酸酶和裂变 - 1,6-双磷酸酶在肝脏中的活性，而血浆胰岛素和肝六酮酶活性在血鳄中显着增加 - 糖尿病大鼠。结论：本研究表明，Cogent DB通过增加糖酵解和降低胰岛素胰岛素的需求而不是未处理的大鼠来控制血糖水平。这是可能的，因为它调节肝葡萄糖代谢酶的活性。

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