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首页> 外文期刊>Diabetes/metabolism research and reviews >Antibodies to oxidized insulin improve prediction of type 1 diabetes in children with positive standard islet autoantibodies
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Antibodies to oxidized insulin improve prediction of type 1 diabetes in children with positive standard islet autoantibodies

机译：抗氧化胰岛素的抗体改善了阳性标准胰岛自身抗体患儿1型糖尿病的预测

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Abstract Background Antibodies to posttranslationally modified insulin (oxPTM‐INS‐Ab) are a novel biomarker of type 1 diabetes (T1D). Here, we evaluated whether oxPTM‐INS‐Ab can improve T1D prediction in children with positive standard islet autoantibodies (AAB). Methods We evaluated sensitivity, specificity, accuracy, and risk for progression to T1D associated with oxPTM‐INS‐Ab and the standard islet AAB that include insulin (IAA), GAD (GADA), and tyrosine phosphatase 2 (IA‐2A) in a cohort of islet AAB‐positive (AAB + ) children from the general population (median follow‐up 8.8?years). Results oxPTM‐INS‐Ab was the most sensitive and specific autoantibody biomarker (74% sensitivity, 91% specificity), followed by IA‐2A (71% sensitivity, 91% specificity). GADA and IAA showed lower sensitivity (65% and 50%, respectively) and specificity (66% and 68%, respectively). Accuracy (AUC of ROC) of oxPTM‐INS‐Ab was higher than GADA and IAA ( P ?=?0.003 and P ?=?0.017, respectively), and similar to IA‐2A ( P ?=?0.896). oxPTM‐INS‐Ab and IA‐2A were more effective than IAA for detecting progr‐T1D when used as second‐line biomarker in GADA + children. Risk for diabetes was higher ( P ?=?0.03) among multiple AAB + who were also oxPTM‐INS‐Ab + compared with those who were oxPTM‐INS‐Ab – . Importantly, when replacing IAA with oxPTM‐INS‐Ab, diabetes risk increased to 100% in children with oxPTM‐INS‐Ab + in combination with GADA + and IA‐2A + , compared with 84.37% in those with IAA + , GADA + , and IA‐2A + ( P ?=?0.04). Conclusions Antibodies to oxidized insulin (oxPTM‐INS‐Ab), compared with IAA which measure autoantibodies to native insulin, improve T1D risk assessment and prediction accuracy in AAB + children.
机译：摘要后期改性胰岛素（OXPTM-INS-AB）的背景抗体是1型糖尿病（T1D）的新型生物标志物。在这里，我们评估了Oxptm-Ins-AB是否可以改善阳性标准胰岛自身抗体（AAB）的儿童的T1D预测。方法评估与OXPTM-INS-AB相关的敏感性，特异性，准确性和患者的敏感性，特异性，准确性和风险，包括胰岛素（IAA），GAD（GADA）和酪氨酸磷酸酶2（IA-2a）的标准胰岛AAb。来自一般人群的胰岛AAB阳性（AAB +）儿童队列（中位于8.8岁以下）。结果Oxptm-Ins-AB是最敏感和特异性的自身抗体生物标志物（74％的灵敏度，91％的特异性），其次是Ia-2a（71％敏感性，91％的特异性）。 Gada和IAA表现出较低的灵敏度（分别为65％和50％）和特异性（分别为66％和68％）。牛塘 - INS-AB的准确性（ROC的AUC）高于GADA和IAA（P？= 0.003和P？= 0.017），类似于IA-2A（P？= 0.896）。当用作GADA +儿童的二线生物标志物时，O​​XPTM-INS-AB和IA-2A更有效地检测PROGR-T1D。与那些是oxptm-an-ab的人相比，糖尿病患者的风险较高（p？= 0.03）。重要的是，当用牛塘IA-AB取代IAA时，糖尿病风险增加到10％的儿童与GADA +和IA-2A +组合增加到100％，而IAA +，GADA +的人则为84.37％。 ，和Ia-2a +（p？= 0.04）。结论抗氧化胰岛素（OXPTM-IN-AB）的抗体，与衡量天然胰岛素的自身抗体，改善AAB +儿童的T1D风险评估和预测准确性。

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