Development and analytical validation of a radioimmunoassay for the quantification of alpha        <sub >1</sub>1        ‐proteinase inhibitor in serum and feces from the common marmoset (        <i >Callithrix jacchusCallithrix jacchus        )

Parambeth Joseph Cyrus; Lidbury Jonathan A.; Suchodolski Jan S.; Steiner J?rg. M.

摘要

Abstract <section numbered="no" xml:id="jmp12375-sec-0001"> <title type="main">Background > The objective of this study was to develop and analytically validate a radioimmunoassay ( <fc>RIA</fc> ) for the measurement of alpha <sub>1</sub> ‐proteinase inhibitor (α <sub>1</sub> ‐ <fc>PI</fc> ) concentrations in serum and feces from the common marmoset. </section> <section numbered="no" xml:id="jmp12375-sec-0002"> <title type="main">Methods > Serum samples (n?=?30) and 3‐day fecal samples (n?=?30) were obtained from healthy marmosets. An <fc>RIA</fc> was established and validated by determination of sensitivity, working range, dilutional parallelism, spiking recovery, and intra‐ and interassay variability. A reference interval for mα <sub>1</sub> ‐ <fc>PI</fc> in serum and feces was established. </section> <section numbered="no" xml:id="jmp12375-sec-0003"> <title type="main">Results > Sensitivity and upper limit of the working range were 0.75 and 100.62?μg/L, respectively. Observed‐to‐expected (O/E) ratios for serial dilutions ranged from 89.9% to 123.0% (mean ± <fc>SD</fc> : 106.0?±?11.5%) for 8 serum samples, and from 90.6% to 132.7% (mean ± <fc>SD</fc> : 107.6?±?19.2%) for 4 fecal samples. O/E ratios for spiking recovery ranged from 97.6% to 104.4% (mean ± <fc>SD</fc> : 101.3?±?3%) for 4 serum samples, and from 97.5% to 101.4% (mean ± <fc>SD</fc> : 99.2?±?1.8%) for 4 fecal samples and 3 different spiking concentrations. Coefficients of v </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：ID =“JMP12375-ABS-ABS-0001”XML：Lang =“en”> <标题类型=“main”>抽象</ title> <sectouned =“no”xml：id = “JMP12375-SEC-0001”> <标题类型=“main”>背景</ title> >本研究的目的是开发和分析用于测量的放射免疫测定（<FC> RIA </ FC>） α<亚> 1 </亚> - 蛋白酶抑制剂（α<亚> 1 </ sub> - <FC> PI </ FC>）血清中的浓度和来自常见的marmoset的粪便。 </ p> </ section> <部分编号=“否”XML：ID =“JMP12375-SEC-0002”> <标题类型=“main”>方法</ title> >血清样本（n？=？ 30）和3天的粪便样品（N？= 30）是从健康的Marmosets获得的。通过测定灵敏度，工作范围，稀释平行，尖刺回收和内部和绕组可变性来建立和验证A <FC> RIA </ FC>。建立了血清和粪便中Mα<sub> 1 </ sub> - <fc> pi </ fc>的参考间隔。 </ p> </ section> <secto numbyed =“no”xml：id =“jmp12375-sec-0003”> <标题类型=“main”>结果</ title> >工作的灵敏度和上限范围分别为0.75和100.62？μg/ l。用于连续稀释液的预期（O / E）比率范围为89.9％至123.0％（平均值±<FC> SD </ FC>：106.0？±11.5％），8次血清样品，90.6％至132.7％（平均值±<FC> SD </ FC>：107.6？±19.2％）4个粪便样品。尖峰恢复的O / E比率从97.6％到104.4％（平均值±<FC> SD </ FC>：101.3？±3％），4血清样品，97.5％至101.4％（平均值±<FC） > SD </ FC>：99.2？±1.8％）4个粪便样品和3种不同的尖峰浓度。 V的系数 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-36449/'>《Journal of medical primatology》</a> <b style="margin: 0 2px;">|</b><span>2018年第6期</span><b style="margin: 0 2px;">|</b><span>共10页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Parambeth Joseph Cyrus&option=202" target="_blank" rel="nofollow">Parambeth Joseph Cyrus;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lidbury Jonathan A.&option=202" target="_blank" rel="nofollow">Lidbury Jonathan A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Suchodolski Jan S.&option=202" target="_blank" rel="nofollow">Suchodolski Jan S.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Steiner J?rg. M.&option=202" target="_blank" rel="nofollow">Steiner J?rg. M.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Gastrointestinal LaboratoryTexas A&</p> <p>M UniversityCollege Station Texas;</p> <p>Gastrointestinal LaboratoryTexas A&</p> <p>M UniversityCollege Station Texas;</p> <p>Gastrointestinal LaboratoryTexas A&</p> <p>M UniversityCollege Station Texas;</p> <p>Gastrointestinal LaboratoryTexas A&</p> <p>M UniversityCollege Station Texas;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/40383.html" title="灵长目">灵长目;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=immunoassay&option=203" rel="nofollow">immunoassay;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=new world primate&option=203" rel="nofollow">new world primate;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=protein‐losing enteropathy&option=203" rel="nofollow">protein‐losing enteropathy;</a> </p> <div class="translation"> 机译：免疫测定;新世界灵长类动物;蛋白质失血肠病; 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Development and analytical validation of a radioimmunoassay for the quantification of alpha 11 ‐proteinase inhibitor in serum and feces from the common marmoset ( Callithrix jacchusCallithrix jacchus )

摘要

Development and analytical validation of a radioimmunoassay for the quantification of alpha ₁1 ‐proteinase inhibitor in serum and feces from the common marmoset ( Callithrix jacchusCallithrix jacchus )