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首页> 外文期刊>American Journal of Nephrology >Correlation of oxidative stress biomarkers and peritoneal urea clearance with mitochondrial DNA copy number in continuous ambulatory peritoneal dialysis patients.
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Correlation of oxidative stress biomarkers and peritoneal urea clearance with mitochondrial DNA copy number in continuous ambulatory peritoneal dialysis patients.

机译：连续非卧床腹膜透析患者中​​氧化应激生物标志物和腹膜尿素清除率与线粒体DNA拷贝数的关系。

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BACKGROUND/AIMS: The influence of oxidative stress and peritoneal clearance on alterations in mitochondrial DNA (mtDNA) copy number in continuous ambulatory peritoneal dialysis (CAPD) patients was investigated. METHODS: Ninety-one CAPD patients (age, 30-57 years) and 99 age-matched healthy subjects were enrolled. Biochemical variables, plasma thiobarbituric-acid-reactive substances (TBARS), free thiol levels and mtDNA copy number in peripheral leukocytes were measured. RESULTS: CAPD patients showed higher TBARS levels, lower free thiol levels and a higher mtDNA copy number than control subjects. Plasma TBARS levels and peritoneal urea clearance were significant factors contributing positively to leukocyte mtDNA copy number (p = 0.024, R(2) = 0.238). The CAPD patients were further categorized into 4 groups depending on whether the TBARS and free thiol plasma levels were above or below the mean values for these parameters. Patients with higher TBARS levels and lower free thiol levels had a significantly higher number of leukocyte mtDNA copies than patients with lower TBARS levels and higher free thiol levels (multi-covariate ANOVA, p = 0.008). CONCLUSION: This study demonstrated that CAPD patients have higher oxidative stress than healthy subjects; such elevated oxidative stress and peritoneal urea clearance have a positive correlation with mtDNA copy number in peripheral leukocytes.
机译：背景/目的：研究了连续性非卧床腹膜透析（CAPD）患者氧化应激和腹膜清除率对线粒体DNA（mtDNA）拷贝数变化的影响。方法：招募了91名CAPD患者（年龄在30-57岁之间）和99名年龄匹配的健康受试者。测量了外周血白细胞中的生化变量，血浆硫代巴比妥酸反应性物质（TBARS），游离硫醇水平和mtDNA拷贝数。结果：与对照组相比，CAPD患者表现出更高的TBARS水平，更低的游离巯基水平和更高的mtDNA拷贝数。血浆TBARS水平和腹膜尿素清除率是对白细胞mtDNA拷贝数有积极贡献的重要因素（p = 0.024，R（2）= 0.238）。根据TBARS和游离硫醇血浆水平是高于还是低于这些参数的平均值，CAPD患者被进一步分为4组。具有较高TBARS水平和较低游离硫醇水平的患者比具有较低TBARS水平和较高游离硫醇水平的患者具有更高的白细胞mtDNA拷贝数（多元协方差分析，p = 0.008）。结论：这项研究表明CAPD患者比健康受试者具有更高的氧化应激。这种升高的氧化应激和腹膜尿素清除率与外周血白细胞的mtDNA拷贝数呈正相关。

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