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首页> 外文期刊>Journal of X-ray science and technology >Increased separability of K-edge nanoparticles by photon-counting detectors for spectral micro-CT
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Increased separability of K-edge nanoparticles by photon-counting detectors for spectral micro-CT

机译：通过光子计数探测器用于光谱微型CT的光子计数探测器的可分离性增加

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BACKGROUND:X-ray CT/micro-CT methods with photon-counting detectors (PCDs) and high Z materials are a hot research topic. One method using PCDs allows for spectral imaging in 5 energy windows while conventional X-ray detectors only collect energy-integrating data. OBJECTIVE:To demonstrate the enhanced separation of contrast materials by using PCDs, multivariate analysis, and linear discriminant methods. METHODS:Phantoms containing iodine and aqueous nanomaterials were scanned on a MARS spectral micro-CT. Image volumes were segmented into separate material-specific populations. Contrast comparisons were made by calculating T2 test statistics in the univariate, pseudo-conventional and multivariate, spectral CT data sets. Separability after Fisher discriminant analysis (FDA) was also assessed. RESULTS:The T2 values calculated for material comparisons increased as a result of the spectral expansion. The majority of the tested contrast agents showed increased T2 values by a factor of ～2 -3. The total significant T2 statistics in the pure and mixed lanthanide image sets increased in the spectral data set. CONCLUSION:This work consolidates the groundwork for photon-counting-based material decomposition with micro-CT, facilitating future development of novel nanomaterials and their preclinical applications.
机译：背景：具有光子计数探测器（PCD）和高Z材料的X射线CT / Micro-CT方法是一个热门的研究主题。使用PCD的一种方法允许在5个能量窗口中进行光谱成像，而传统的X射线检测器仅收集能量集成数据。目的：通过使用PCD，多变量分析和线性判别方法来证明造影材料的增强分离。方法：在火星光谱微型CT上扫描含碘和纳米材料的含碘和水性纳米材料的幽灵。图像量被分段为单独的材料特征群体。通过计算单变量，伪常规和多变量，光谱CT数据集的T2测试统计来进行对比比较。还评估了Fisher判别分析（FDA）后的可分离性。结果：由于光谱膨胀，用于材料比较的T2值增加。大多数测试的造影剂显示出T2值的增加〜2-3倍。纯和混合镧系元素图像集中的总显着T2统计在光谱数据集中增加。结论：这项工作巩固了基于光子计数的基于材料分解的基础，用微型CT，促进了新型纳米材料的未来发展及其临床前应用。

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