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首页> 外文期刊>Journal of cellular biochemistry. >The caveolar membrane system in endothelium: From cell signaling to vascular pathology
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The caveolar membrane system in endothelium: From cell signaling to vascular pathology

机译：内皮中的Caveolar膜系统：从细胞信号传导到血管病理学

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摘要

Abstract Caveolae are 50‐ to 100‐nm cholesterol and glycosphingolipid‐rich flask‐shaped invaginations commonly observed in many terminally differentiated cells. These organelles have been described in many cell types and are particularly abundant in endothelial cells, where they have been involved in the regulation of certain signaling pathways. Specific scaffolding proteins termed caveolins, along with the more recently discovered members of the cavin family, represent the major protein components during caveolae biogenesis. In addition, multiple studies aimed to investigate the expression and the regulation of these proteins significantly contributed to elucidate the role of caveolae and caveolins in endothelial cell physiology and disease. The aim of this review is to survey recent evidence of the involvement of the caveolar network in endothelial cell biology and endothelial cell dysfunction.
机译：摘要Caveolae是50至100nm胆固醇和富含糖磷脂的烧瓶形状的血管，通常在许多终端分化的细胞中观察到。 这些细胞器已在许多细胞类型中描述，并且在内皮细胞中特别丰富，在那里它们参与了某些信号通路的调节。 被称为Cavolins的特异性支架蛋白质，以及最近发现的Cavin家族的成员，代表Caveolae生物发生期间的主要蛋白质组分。 此外，旨在研究这些蛋白质的表达和调节的多项研究显着促进了Caveolae和Cavolins在内皮细胞生理和疾病中的作用。 本综述的目的是调查最近Caveolar Network在内皮细胞生物学和内皮细胞功能障碍中涉及的证据。

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