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首页> 外文期刊>Journal of cellular biochemistry. >The effect of plant lectins on the survival and malignant behaviors of thyroid cancer cells
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The effect of plant lectins on the survival and malignant behaviors of thyroid cancer cells

机译：植物凝集对甲状腺癌细胞存活和恶性行为的影响

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Abstract Altered or aberrant glycosylation is a common phenomenon in cancer cells and it originates from changes in the expression of the enzymes, glycosyltransferase, and glycosidase which up‐regulate in response to some oncogenes in the glycan synthesis pathway. In this present study, it has been aimed to determine the alteration of sialic acid and fucose expressions in the cell surface of human thyroid carcinoma cells and investigate the changes in tumorigenic and malignant characters after treating them with specific plant lectins. Our study showed that the cell surface glycan chains of anaplastic 8305C, follicular FTC‐133, and papillary K1 thyroid carcinoma cells were rich in α‐2,6, α‐2,3, sialic acid, and α‐1,6 fucose residues. When the cells were treated with specific doses of Maackia amurensis lectin II (MAL), Sambucus nigra agglutinin (SNA), and Aleuria aurantia lectin (AAL) which have specific binding capacity for the detected glycan residues, respectively their cancerous traits changed dramatically. Remarkable findings obtained from MAL treatment leading to necrosis in 8505C cells without any toxicity for normal thyroid epithelial cells but it had proliferative effect on K1 and FCT‐133 cells. Besides, MAL and SNA treatment decreased the mobility of 8505C and K1 cells. MAL and SNA lectins dramatically reduced the endothelial affinity of the cells and AAL significantly attenuated that of 8050C and K1 cells but not FTC‐133. These results suggest that altered cell surface glycosylation in thyroid cancer seems to be a strong candidate for developing new therapeutic strategies.
机译：摘要改变或异常的糖基化是癌细胞中的常见现象，并且它起源于酶，糖基转移酶和糖苷酶的表达的变化，该糖苷酶响应于聚糖合成途径中的一些癌基因的调节而上调。在本研究中，旨在确定人甲状腺癌细胞细胞表面中唾液酸和岩藻糖表达的改变，并在用特定植物凝集素治疗它们后调查致瘤和恶性肿瘤的变化。我们的研究表明，芳塑形8305C，滤泡FTC-133和乳头K1甲状腺癌细胞中富含α-2,6，α-2,3，唾液酸和α-1,6岩藻糖残基的细胞表面甘油链。当细胞用特定剂量的Maackia Amurensis凝集素II（MAL），SAMBucus nigra凝集素（SNA）和具有特异性糖粉残留物的特异性结合能力的血管菌凝集素（AA1）分别进行了癌症的特异性的癌症。从MAL治疗中获得的显着发现导致8505℃细胞中的坏死，没有正常甲状腺上皮细胞的任何毒性，但它对K1和FCT-133细胞具有增殖作用。此外，MAL和SNA治疗降低了8505℃和K1细胞的迁移率。 MAL和SNA凝集素显着降低了细胞的内皮亲和力，并且AA1显着减弱了805℃和K1细胞但不是FTC-133。这些结果表明，甲状腺癌中的细胞表面糖基化改变似乎是开发新的治疗策略的强烈候选者。

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