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首页> 外文期刊>American Journal of Pathology: Official Publication of the American Association of Pathologists >Plasmacytoid dendritic cells control lung inflammation and monocyte recruitment in indirect acute lung injury in mice.
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Plasmacytoid dendritic cells control lung inflammation and monocyte recruitment in indirect acute lung injury in mice.

机译：浆细胞样树突状细胞控制小鼠间接急性肺损伤中的肺部炎症和单核细胞募集。

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摘要

Indirect acute lung injury (ALI, not caused by a direct insult to the lung) represents the first organ dysfunction in trauma patients, with nonpulmonary sepsis being the most common cause of indirect ALI. Dendritic cells (DCs) are thought to participate in a number of inflammatory lung diseases; however, their role in indirect ALI is currently not established. Using a clinically relevant model of indirect ALI induced in mice by hemorrhagic shock followed 24 hours later by polymicrobial septic challenge, we report that mature DC numbers were markedly increased in the lung during indirect ALI. DC depletion induced a significant increase in indirect ALI severity, which was associated with enhanced lung and plasma proinflammatory cytokine concentration and recruitment of proinflammatory CD115(+) monocytes in response to increased lung monocyte chemotactic protein-1 production. Among the different DC subpopulations, plasmacytoid DCs, which were induced and activated in the lung during indirect ALI, were responsible for this effect because their specific depletion reproduced the observations made in DC-depleted mice. As the recruitment of monocytes to the lung plays a central deleterious role in the pathophysiology of indirect ALI, our data therefore position plasmacytoid DCs as important regulators of acute lung inflammation.
机译：间接急性肺损伤（ALI，不是由对肺的直接伤害引起的）代表创伤患者的首个器官功能障碍，其中非肺败血症是间接ALI的最常见原因。树突状细胞（DC）被认为参与多种炎症性肺病;但是，它们在间接ALI中的作用目前尚未确定。使用失血性休克在小鼠中诱发的间接ALI的临床相关模型，然后在24小时后通过多药败血症激发，我们发现间接ALI期间成熟的DC数量在肺中显着增加。 DC耗竭引起间接ALI严重程度的显着增加，这与肺和血浆促炎细胞因子浓度的增加以及对肺单核细胞趋化蛋白1产生增加的促炎CD115（+）单核细胞的募集有关。在不同的DC亚群中，间接ALI期间在肺中被诱导并激活的浆细胞样DC负责这种效应，因为它们的特定消耗可再现DC消耗小鼠的观察结果。由于单核细胞向肺的募集在间接ALI的病理生理中起着重要的有害作用，因此我们的数据将浆细胞样DC定位为急性肺炎症的重要调节剂。

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