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首页> 外文期刊>Biotechnology Advances: An International Review Journal >Advances in plant molecular farming.
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Advances in plant molecular farming.

机译：植物分子农业的进展。

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Plant molecular farming (PMF) is a new branch of plant biotechnology, where plants are engineered to produce recombinant pharmaceutical and industrial proteins in large quantities. As an emerging subdivision of the biopharmaceutical industry, PMF is still trying to gain comparable social acceptance as the already established production systems that produce these high valued proteins in microbial, yeast, or mammalian expression systems. This article reviews the various cost-effective technologies and strategies, which are being developed to improve yield and quality of the plant-derived pharmaceuticals, thereby making plant-based production system suitable alternatives to the existing systems. It also attempts to overview the different novel plant-derived pharmaceuticals and non-pharmaceutical protein products that are at various stages of clinical development or commercialization. It then discusses the biosafety and regulatory issues, which are crucial (if strictly adhered to) to eliminating potential health and environmental risks, which in turn is necessary to earning favorable public perception, thus ensuring the success of the industry.Digital Object Identifier http://dx.doi.org/10.1016/j.biotechadv.2010.11.004
机译：植物分子耕种（PMF）是植物生物技术的一个新分支，在这里植物被改造成可大量生产重组药物和工业蛋白质的植物。作为生物制药行业的新兴分支，PMF仍在努力获得可比的社会认可，因为它们已经建立了在微生物，酵母或哺乳动物表达系统中生产这些高价值蛋白质的生产系统。本文介绍了各种成本有效的技术和策略，这些技术和策略正在开发中，以提高植物来源药物的产量和质量，从而使基于植物的生产系统成为现有系统的合适替代品。它还试图概述处于临床开发或商业化各个阶段的不同的新型植物来源的药物和非药物蛋白产品。然后讨论了生物安全和监管问题，这些问题对于消除潜在的健康和环境风险至关重要（如果严格遵守的话），而这又对于赢得公众的认可是必不可少的，从而确保了行业的成功。 //dx.doi.org/10.1016/j.biotechadv.2010.11.004

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