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Parasitic fungus Claviceps as a source for biotechnological production of ergot alkaloids.

机译:寄生真菌棒状杆菌作为麦角生物碱生物技术生产的来源。

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Ergot alkaloids produced by the fungus Claviceps parasitizing on cereals, include three major groups: clavine alkaloids, d-lysergic acid and its derivatives and ergopeptines. These alkaloids are important substances for the pharmatech industry, where they are used for production of anti-migraine drugs, uterotonics, prolactin inhibitors, anti-Parkinson agents, etc. Production of ergot alkaloids is based either on traditional field cultivation of ergot-infected rye or on submerged cultures of the fungus in industrial fermentation plants. In 2010, the total production of these alkaloids in the world was about 20,000 kg, of which field cultivation contributed about 50%. This review covers the recent advances in understanding of the genetics and regulation of biosynthesis of ergot alkaloids, focusing on possible applications of the new knowledge to improve the production yield.Digital Object Identifier http://dx.doi.org/10.1016/j.biotechadv.2012.01.005
机译:寄生于谷物上的锁骨头孢菌产生的麦角生物碱包括三大类:锁骨碱生物碱,d-麦角酸及其衍生物和麦角肽碱。这些生物碱是制药工业的重要物质,可用于生产抗偏头痛药物,子宫缩酮药,催乳素抑制剂,抗帕金森氏剂等。麦角生物碱的生产基于对麦角感染黑麦的传统田间栽培或工业发酵工厂中真菌的深层培养。 2010年,世界上这些生物碱的总产量约为20,000公斤,其中田间耕种贡献了约50%。这篇综述涵盖了麦角生物碱的遗传学和生物合成调控的最新进展,重点是可能应用新知识来提高产量。数字对象标识符http://dx.doi.org/10.1016/j。 2012.01.005

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