...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biotechnology Advances: An International Review Journal >Nanomaterial scaffolds for stem cell proliferation and differentiation in tissue engineering
【24h】

Nanomaterial scaffolds for stem cell proliferation and differentiation in tissue engineering

机译：用于组织工程中干细胞增殖和分化的纳米材料支架

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Tissue engineering is a clinically driven field and has emerged as a potential alternative to organ transplantation. The cornerstone of successful tissue engineering rests upon two essential elements: cells and scaffolds. Recently, it was found that stem cells have unique capabilities of self-renewal and multilineage differentiation to serve as a versatile cell source, while nanomaterials have lately emerged as promising candidates in producing scaffolds able to better mimic the nanostructure in natural extracellular matrix and to efficiently replace defective tissues. This article, therefore, reviews the key developments in tissue engineering, where the combination of stem cells and nanomaterial scaffolds has been utilized over the past several years. We consider the high potential, as well as the main issues related to the application of stem cells and nanomaterial scaffolds for a range of tissues including bone, cartilage, nerve, liver, eye etc. Promising in vitro results such as efficient attachment, proliferation and differentiation of stem cells have been compiled in a series of examples involving different nanomaterials. Furthermore, the merits of the marriage of stem cells and nanomaterial scaffolds are also demonstrated in vivo, providing early successes to support subsequent clinical investigations. This progress simultaneously drives mechanistic research into the mechanotransduction process responsible for the observations in order to optimize the process further. Current understanding is chiefly reported to involve the interaction of stem cells and the anchoring nanomaterial scaffolds by activating various signaling pathways. Substrate surface characteristics and scaffold bulk properties are also reported to influence not only short term stem cell adhesion, spreading and proliferation, but also longer term lineage differentiation, functionalization and viability. It is expected that the combination of stem cells and nanomaterials will develop into an important tool in tissue engineering for the innovative treatment of many diseases
机译：组织工程学是临床驱动领域，已成为器官移植的潜在替代方法。成功的组织工程学的基础在于两个基本要素：细胞和支架。最近，发现干细胞具有独特的自我更新和多谱系分化能力，可以用作多用途细胞来源，而近来，纳米材料已成为制造支架的有前途的候选者，这些支架能够更好地模仿天然细胞外基质中的纳米结构并有效地更换有缺陷的纸巾。因此，本文回顾了组织工程学中的关键发展，在过去的几年中，干细胞和纳米材料支架的组合得到了利用。我们考虑到干细胞和纳米材料支架在包括骨骼，软骨，神经，肝，眼等在内的多种组织中应用的巨大潜力以及主要问题。有希望的体外结果，如有效的附着，增殖和增殖在涉及不同纳米材料的一系列实例中已经汇编了干细胞的分化。此外，在体内还证明了干细胞与纳米材料支架结合的优点，为支持后续的临床研究提供了早期成功。这一进展同时推动了对负责观测的机械转导过程的机理研究，从而进一步优化了过程。主要报道了目前的理解，其涉及通过激活各种信号传导途径来使干细胞与锚定纳米材料支架相互作用。还报道了底物表面特征和支架整体性质不仅影响短期干细胞粘附，扩散和增殖，而且影响长期谱系分化，功能化和生存力。预计干细胞和纳米材料的结合将发展成为组织工程学中创新治疗多种疾病的重要工具

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号