Biotransformations and biological activities of hop flavonoids

Karabin Marcel; Hudcova Tereza; Jelinek Lukas; Dostalek Pavel

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Biotransformations and biological activities of hop flavonoids

机译：蛇麻草黄酮的生物转化和生物活性

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Female hop cones are used extensively in the brewing industry, but there is now increasing interest in possible uses of hops for non-brewing purposes, especially in the pharmaceutical industry. Among pharmaceutically important compounds from hops are flavonoids, having proven anticarcinogenic, antioxidant, antimicrobial, anti-inflammatory and estrogenic effects. In this review we aim to present current knowledge on the biotransformation of flavonoids from hop cones with respect to products, catalysis and conversion. A list of microbial enzymatic reactions associated with gastrointestinal microbiota is presented. A comparative analysis of the biological activities of hop flavonoids and their biotransformation products is described, indicating where further research has potential for applications in the pharmaceutical industry. (C) 2015 Elsevier Inc. All rights reserved.

机译：酒花锥在酿造行业中得到广泛使用，但现在人们越来越有可能将酒花用于非酿造目的，特别是在制药行业。啤酒花中重要的药用化合物是类黄酮，它们具有抗癌，抗氧化，抗微生物，抗炎和雌激素作用。在这篇综述中，我们旨在介绍有关啤酒花球果中黄酮类化合物的生物转化有关产物，催化和转化的最新知识。列出了与胃肠道微生物群有关的微生物酶促反应清单。描述了蛇麻草类黄酮及其生物转化产物的生物学活性的比较分析，表明进一步的研究在制药工业中的应用潜力。（C）2015 Elsevier Inc.保留所有权利。

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来源
《Biotechnology Advances: An International Review Journal》 |2015年第2期|共28页
作者
Karabin Marcel; Hudcova Tereza; Jelinek Lukas; Dostalek Pavel;
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正文语种 eng
中图分类生物工程学（生物技术）;
关键词
Hop; Flavonoid; Biotransformation; Prenylation; Methylation; Demethylation; Glycosylation; Deglycosylation; Hydroxylation; Acylation;

机译：蛇麻草;类黄酮;生物转化;异戊烯基化;甲基化;去甲基化;糖基化;去糖基化;羟基化;酰化;

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1. Biotransformations and biological activities of hop flavonoids [J] . Karabin Marcel, Hudcova Tereza, Jelinek Lukas, Biotechnology Advances: An International Review Journal . 2015,第6aPta2期

机译：蛇麻草黄酮的生物转化和生物活性
2. In vitro biotransformation of xanthohumol, a flavonoid from hops (Humulus lupulus), by rat liver microsomes. [J] . Yilmazer M, Stevens JF, Deinzer ML, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2001,第3期

机译：大鼠肝微粒体对黄花hu酚（一种来自啤酒花（Hu）的类黄酮）的体外生物转化。
3. Isoxanthohumol - Biologically active hop flavonoid [J] . Zolnierczyk Anna Katarzyna, Maczka Wanda Krystyna, Grabarczyk Malgorzata, Fitoterapia . 2015,第Null期

机译：异黄腐酚-具有生物活性的啤酒花黄酮
4. Synthesis, Characterization and Biological Activity of Flavonoid Derivatives with Amine [C] . Sheetal Shrimal, Anamika Jain National Conference on Physics and Chemistry of Materials . 2019

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5. A study of major flavonoid compounds and analysis of total phenols, total flavonoids, and antioxidant activity in the leaves, stems, roots, and flowers of Sesbania grandiflora. [D] . Ghosh, Rajarshi. 2014

机译：研究大叶黄柏中主要黄酮类化合物并分析其总酚，总黄酮和叶，茎，根和花中的抗氧化活性。
6. Stemodane Diterpenes and Diterpenoids: Isolation Structure Elucidation Biogenesis Biosynthesis Biological Activity Biotransformations Metabolites and Derivatives Biological Activity Rearrangements [O] . Francesca Leonelli, Luisa Maria Migneco, Alessio Valletta, 2021

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7. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids [O] . Milligan, S R, Kalita, J C, Pocock, V, 2000

机译：8-异戊烯基柚皮苷和相关蛇麻草类黄酮的内分泌活性

Biotransformations and biological activities of hop flavonoids

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