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首页> 外文期刊>Biotechnology Advances: An International Review Journal >Molecular targets for detection and immunotherapy in Cryptosporidium parvum.
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Molecular targets for detection and immunotherapy in Cryptosporidium parvum.

机译：小隐孢子虫的检测和免疫疗法的分子靶标。

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Cryptosporidium parvum is an obligate protozoan parasite responsible for the diarrheal illness cryptosporidiosis in humans and animals. Although C. parvum is particularly pathogenic in immunocompromised hosts, the molecular mechanisms by which C. parvum invades the host epithelial cells are not well understood. Characterization of molecular-based antigenic targets of C. parvum is required to improve the specificity of detection, viability assessments, and immunotherapy (treatment). A number of zoite surface (glyco)proteins are known to be expressed during, and believed to be involved in, invasion and infection of host epithelial cells. In the absence of protective treatments for this illness, antibodies targeted against these zoite surface (glyco)proteins offers a rational approach to therapy. Monoclonal, polyclonal and recombinant antibodies represent useful immunotherapeutic means of combating infection, especially when highly immunogenic C. parvum antigens are utilized as targets. Interruption of life cycle stages of this parasite via antibodies that target critical surface-exposed proteins can potentially decrease the severity of disease symptoms and subsequent re-infection of host tissues. In addition, development of vaccines to this parasite based on the same antigens may be a valuable means of preventing infection. This paper describes many of the zoite surface glycoproteins potentially involved in infection, as well as summarizes many of the immunotherapeutic studies completed to date. The identification and characterization of antibodies that bind to C. parvum-specific cell surface antigens of the oocyst and sporozoite will allow researchers to fully realize the potential of molecular-based immunotherapy to this parasite.
机译：小隐孢子虫是专性原生动物寄生虫，负责人类和动物的腹泻病隐孢子虫病。尽管细小隐孢子虫在免疫受损的宿主中特别致病，但是尚不完全了解小隐隐孢子虫侵入宿主上皮细胞的分子机制。为了提高检测，生存力评估和免疫疗法（治疗）的特异性，需要鉴定小球藻的基于分子的抗原靶标。已知许多zoite表面（糖）蛋白在宿主上皮细胞的侵袭和感染期间表达，并且据信与宿主上皮细胞的侵袭和感染有关。在没有针对这种疾病的保护性治疗的情况下，针对这些动物表面（糖）蛋白的抗体提供了一种合理的治疗方法。单克隆，多克隆和重组抗体代表了对抗感染的有效免疫治疗手段，尤其是在高度免疫原性小球隐孢子虫抗原用作靶标的情况下。通过靶向关键表面暴露蛋白的抗体中断该寄生虫的生命周期阶段，可能会降低疾病症状的严重程度以及随后对宿主组织的再次感染。另外，基于相同抗原开发针对该寄生虫的疫苗可能是预防感染的有价值的手段。本文描述了许多可能与感染有关的沸石表面糖蛋白，并总结了迄今为止完成的许多免疫治疗研究。与卵囊和子孢子的小隐孢子虫特异性细胞表面抗原结合的抗体的鉴定和表征将使研究人员充分认识到对该寄生虫进行分子免疫治疗的潜力。

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