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首页> 外文期刊>American Journal of Obstetrics and Gynecology >The economic impact of HPV vaccines: not just cervical cancer.
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The economic impact of HPV vaccines: not just cervical cancer.

机译：HPV疫苗的经济影响：不仅是宫颈癌。

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摘要

Cervical cancer is the leading cause of cancer death among women worldwide. Although regular screening dramatically reduces the incidence and death from cervical cancer, effective screening requires substantial investment of resources to ensure adequate population coverage, acceptable test performance, and appropriate management of abnormal results. The discovery that cervical cancer was caused by human pap-illomavirus(HPV) led rapidly to the development of vaccines targeted against HPV-16 and -18, which account for approximately 70% of cancer cases.1 These vaccines are 90%-100% effective in reducing the incidence of persistent infection and cervical lesions, which includes CIN 2/3, with these viral types. Based on these data, mathematic modeling studies consistently have estimated that vaccination will result in a substantial reduction in the burden of cervical disease. Based on current prices of the available vaccine, vaccination is unlikely to be cost-saving (ie, the overall costs of a vaccine program are higher than the costs of not vaccinating), but the cost-effectiveness-the price paid for gains in life expectancy and quality of life-is generally within a range that is considered acceptable and is comparable to other preventive measures, such as mammography.
机译：宫颈癌是全世界女性癌症死亡的主要原因。尽管定期筛查可大大降低子宫颈癌的发病率和死亡率，但有效筛查需要投入大量资源以确保足够的人群覆盖率，可接受的测试性能以及对异常结果的适当管理。宫颈癌是由人乳头瘤病毒（HPV）引起的发现迅速导致了针对HPV-16和-18的疫苗的开发，约占癌症病例的70％。1这些疫苗占90％-100％这些病毒类型可有效降低持续感染和宫颈病变（包括CIN 2/3）的发生率。基于这些数据，数学模型研究始终估计接种疫苗将大大减少子宫颈疾病的负担。根据现有疫苗的当前价格，疫苗接种不太可能节省成本（即，疫苗计划的总成本高于不接种疫苗的成本），但是成本效益是为获得生命所付出的代价预期寿命和生活质量-通常在可以接受的范围内，并且可以与其他预防措施（如乳房X线照相术）相媲美。

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