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首页> 外文期刊>American Journal of Obstetrics and Gynecology >Menopausal quality of life: RCT of yoga, exercise, and omega-3 supplements
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Menopausal quality of life: RCT of yoga, exercise, and omega-3 supplements

机译：更年期生活质量：瑜伽，运动和omega-3补充剂的RCT

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Objective The purpose of this study was to determine the efficacy of 3 nonhormonal therapies for the improvement of menopause-related quality of life in women with vasomotor symptoms. Study Design We conducted a 12-week 3 × 2 randomized, controlled, factorial design trial. Peri- and postmenopausal women, 40-62 years old, were assigned randomly to yoga (n = 107), exercise (n = 106), or usual activity (n = 142) and also assigned randomly to a double-blind comparison of omega-3 (n = 177) or placebo (n = 178) capsules. We performed the following interventions: (1) weekly 90-minute yoga classes with daily at-home practice, (2) individualized facility-based aerobic exercise training 3 times/week, and (3) 0.615 g omega-3 supplement, 3 times/day. The outcomes were assessed with the following scores: Menopausal Quality of Life Questionnaire (MENQOL) total and domain (vasomotor symptoms, psychosocial, physical and sexual). Results Among 355 randomly assigned women who average age was 54.7 years, 338 women (95%) completed 12-week assessments. Mean baseline vasomotor symptoms frequency was 7.6/day, and the mean baseline total MENQOL score was 3.8 (range, 1-8 from better to worse) with no between-group differences. For yoga compared to usual activity, baseline to 12-week improvements were seen for MENQOL total -0.3 (95% confidence interval, -0.6 to 0; P =.02), vasomotor symptom domain (P =.02), and sexuality domain (P =.03) scores. For women who underwent exercise and omega-3 therapy compared with control subjects, improvements in baseline to 12-week total MENQOL scores were not observed. Exercise showed benefit in the MENQOL physical domain score at 12 weeks (P =.02). Conclusion All women become menopausal, and many of them seek medical advice on ways to improve quality of life; little evidence-based information exists. We found that, among healthy sedentary menopausal women, yoga appears to improve menopausal quality of life; the clinical significance of our finding is uncertain because of the modest effect.
机译：目的本研究的目的是确定3种非激素疗法对改善具有血管舒缩症状的女性绝经相关的生活质量的功效。研究设计我们进行了为期12周的3×2随机，对照，析因设计试验。 40-62岁的围绝经期和绝经后妇女被随机分配给瑜伽（n = 107），运动（n = 106）或日常活动（n = 142），并且还被随机分配给欧米茄进行双盲比较-3（n = 177）或安慰剂（n = 178）胶囊。我们进行了以下干预：（1）每周进行90分钟的瑜伽课，每天在家进行练习;（2）个性化的基于设施的有氧运动训练，每周3次，（3）0.615 g omega-3补充剂，3次/天。用以下分数评估结局：更年期生活质量调查表（MENQOL）总体和范围（血管舒缩症状，社会心理，身体和性行为）。结果在355名平均年龄为54.7岁的女性中，有338名女性（95％）完成了为期12周的评估。平均基线血管舒缩症状频率为7.6 /天，平均基线MENQOL总评分为3.8（范围从好到差的1-8），组间无差异。对于瑜伽而言，与通常的活动相比，MENQOL的总体基线改善为-0.3（95％置信区间，-0.6为0; P = .02），血管舒缩症状域（P = .02）和性能力域改善了12周（P = .03）得分。与对照组相比，接受运动和omega-3治疗的女性未观察到MENQOL总分基线改善到12周。运动在12周时显示出对MENQOL物理领域评分的益处（P = .02）。结论所有妇女均已绝经，其中许多人就改善生活质量的方式寻求医学建议。几乎没有循证信息。我们发现，在健康的久坐更年期妇女中，瑜伽似乎可以改善更年期的生活质量。由于疗效不佳，我们发现的临床意义尚不确定。

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