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首页> 外文期刊>日本農芸化学会誌 >Effects of rosemary, plantago, and tea tree oil on the capsaicin-induced coughs in guinea pigs [Japanese]
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Effects of rosemary, plantago, and tea tree oil on the capsaicin-induced coughs in guinea pigs [Japanese]

机译：迷迭香，Plangago和茶树油对豚鼠辣椒素咳嗽的影响[日文]

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Rosemary, plantago, and tea tree oil have been customarily used for the treatment of the common cold, but the detailed mechanisms of these antitussive effects are not well known. Thus, the aim of this study was to assess the antitussive properties of these herbs using a capsaicin-induced cough model in guinea pigs. Rosemary (10, 30 muL/kg, p.o.), plantago (10, 30 mg/kg, p.o.), and tea tree oil (10, 30 muL/kg, p.o.) produced dose-dependent and significant antitussive effects. Methysergide (a serotonin receptor antagonist), but not naloxone (a opioid receptor antagonist), antagonize the antitussive effects of plantago and tea tree oil. On the other hand, neither methysergid nor naloxone had a significant effect on the antitussive effect of rosemary. Furthermore, gamma-terpinene, terpinene-4-ol, cineole, and alpha-pinene, main components of tea tree oil and rosemary, significantly inhibited the number of capsaicin-induced coughs in guinea pigs. These results suggest that the antitussive effects of plantago and tea tree oil may depend on central mechanisms (modulation of serotonergic systems). On the other hand, the antitussive effects of rosemary may depend on peripheral mechanisms. Furthermore, it is suggested that gamma-terpinene, terpinene-4-ol, cineole, and alpha-pinene may play an important role in the antitussive effects of tea tree oil and rosemary.
机译：迷迭香，帕特拉戈和茶树油已习惯用于治疗普通感冒，但这些镇咳效应的详细机制尚不清楚。因此，本研究的目的是利用豚鼠中的辣椒素诱导的咳嗽模型评估这些草药的镇咳性质。迷迭香（10,30 MuL / kg，p.o.），跖甲（10,30 mg / kg，p.o.）和茶树油（10,30,30 mul / kg，p.o.）产生了剂量依赖性和显着的镇咳效果。甲虫酮（血清素受体拮抗剂），但不是纳洛酮（阿片类受体拮抗剂），拮抗植物和茶树油的镇咳效果。另一方面，甲酸盐和纳洛酮都没有对迷迭香的镇咳效应产生显着影响。此外，γ-萜烯，萜烯-4-醇，豆脂和α-甲烯，茶树油和迷迭香的主要成分，显着抑制了豚鼠中辣椒素诱导的咳嗽的数量。这些结果表明，跖跖和茶树油的镇咳效应可能取决于中枢机制（血清onOronery系统的调节）。另一方面，迷迭香的镇咳效应可能取决于外围机制。此外，建议γ-萜烯，萜烯-4-醇，鳞片和α-甲烯可能在茶树油和迷迭香的镇咳效应中起重要作用。

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