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首页> 外文期刊>日本農芸化学会誌 >Effects of rosemary, plantago, and tea tree oil on the capsaicin-induced coughs in guinea pigs [Japanese]
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Effects of rosemary, plantago, and tea tree oil on the capsaicin-induced coughs in guinea pigs [Japanese]

机译：迷迭香，车前子和茶树油对辣椒素引起的豚鼠咳嗽的作用[日语]

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Rosemary, plantago, and tea tree oil have been customarily used for the treatment of the common cold, but the detailed mechanisms of these antitussive effects are not well known. Thus, the aim of this study was to assess the antitussive properties of these herbs using a capsaicin-induced cough model in guinea pigs. Rosemary (10, 30 muL/kg, p.o.), plantago (10, 30 mg/kg, p.o.), and tea tree oil (10, 30 muL/kg, p.o.) produced dose-dependent and significant antitussive effects. Methysergide (a serotonin receptor antagonist), but not naloxone (a opioid receptor antagonist), antagonize the antitussive effects of plantago and tea tree oil. On the other hand, neither methysergid nor naloxone had a significant effect on the antitussive effect of rosemary. Furthermore, gamma-terpinene, terpinene-4-ol, cineole, and alpha-pinene, main components of tea tree oil and rosemary, significantly inhibited the number of capsaicin-induced coughs in guinea pigs. These results suggest that the antitussive effects of plantago and tea tree oil may depend on central mechanisms (modulation of serotonergic systems). On the other hand, the antitussive effects of rosemary may depend on peripheral mechanisms. Furthermore, it is suggested that gamma-terpinene, terpinene-4-ol, cineole, and alpha-pinene may play an important role in the antitussive effects of tea tree oil and rosemary.
机译：迷迭香，车前子和茶树油已习惯用于感冒的治疗，但是这些镇咳作用的详细机制尚不清楚。因此，本研究的目的是使用辣椒素诱导的豚鼠咳嗽模型评估这些草药的镇咳特性。迷迭香（10，30μL/ kg，p.o.），车前子（10，30 mg / kg，p.o.）和茶树油（10，30μL/ kg，p.o.）产生剂量依赖性和明显的镇咳作用。 Methysergide（一种5-羟色胺受体拮抗剂）而不是纳洛酮（一种阿片受体拮抗剂）拮抗车前子和茶树油的镇咳作用。另一方面，美塞麦和纳洛酮对迷迭香的镇咳作用均无明显作用。此外，茶树油和迷迭香的主要成分γ-萜品烯，萜品烯-4-醇，桉树脑和α-pine烯显着抑制了辣椒素诱发豚鼠咳嗽的次数。这些结果表明，车前子和茶树油的镇咳作用可能取决于中心机制（5-羟色胺能系统的调节）。另一方面，迷迭香的镇咳作用可能取决于外围机制。此外，建议γ-萜品烯，萜品烯-4-醇，桉树脑和α-pine烯可能在茶树油和迷迭香的镇咳作用中起重要作用。

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