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首页> 外文期刊>American Journal of Obstetrics and Gynecology >Uterine cellular leiomyomata with chromosome 1p deletions represent a distinct entity
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Uterine cellular leiomyomata with chromosome 1p deletions represent a distinct entity

机译：染色体1p缺失的子宫细胞平滑肌瘤代表一个独特的实体

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This study aimed to determine whether 1p deletion defines a subset of cellular leiomyomata (CL), which is a hypercellular variant of uterine leiomyomata that may have delayed malignant potential, and to correlate this genetic change with clinical and pathologic characteristics including those present in uterine sarcomas. STUDY DESIGN: Available CL cases at the Mayo Clinic (n = 101) and variant cases reported in another article (n = 16) were identified. Each case with sufficient tissue that met histologic criteria for CL when reviewed by a single pathologist underwent interphase fluorescence in situ hybridization to determine the presence of 1p deletion. Clinical characteristics of women with confirmed CL were compared on the basis of 1p deletion status using univariate analysis. RESULTS: Of the Mayo Clinic cohort of histologically confirmed CL, 23% had deletion of 1p. Women with this subset of CL, when compared to those without 1p deletion, were more likely to be postmenopausal (P = .049) and their uteri tended to be heavier (P= .039) with a larger dominant leiomyoma (P= .030). The pathologic features associated with 1 p deletion were high cellularity (P -,036) and hyaline necrosis (P = .047), which remained significant after inclusion of the CL cases from a previously published series.
机译：这项研究旨在确定1p缺失是否定义了细胞平滑肌瘤（CL）的子集，CL是子宫平滑肌瘤的一种高细胞变体，可能延迟了恶性潜能，并将这种遗传变化与临床和病理特征（包括子宫肉瘤中的特征）相关联。研究设计：确定了Mayo诊所可用的CL病例（n = 101）和另一篇文章中报道的变异病例（n = 16）。当由一名病理学家检查时，每个具有足够的组织且符合CL组织学标准的病例都进行了相间荧光原位杂交以确定1p缺失的存在。使用单因素分析，根据1p缺失状态比较已确诊CL的女性的临床特征。结果：经组织学证实的CL的梅奥诊所队列中，有23％的患者删除了1p。与没有1p缺失的女性相比，具有这种CL亚型的女性更容易绝经后（P = .049），子宫倾向于较重（P = .039），且伴有较大的优势平滑肌瘤（P = .030）。 ）。与1 p缺失相关的病理学特征是高细胞性（P -036）和透明性坏死（P = .047），在包括先前发表的系列的CL病例后，其仍然很明显。

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