TO THE EDITORS: In 1914, James Young set out a detailed account of the placental findings in preeclampsia. that included the incidence of infarction and villous over-crowding.1 His placental ischemia theory displaced the preceding mechanical distension theory as an explanation of preeclampsia. In 2014, Nelson et al conclude that "preeclampsia is a different disease depending on the gestational age at diagnosis." In their large series, the placental findings at <34 weeks' gestation include signs of placental ischemia, small placentae, and small-for-gestational-age fetuses; whereas at >34 weeks' gestation, there are larger placentae with appropriate-for-gestational-age fetuses.
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