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首页> 外文期刊>American Journal of Obstetrics and Gynecology >The effect of prenatal pravastatin treatment on altered fetal programming of postnatal growth and metabolic function in a preeclampsia-like murine model
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The effect of prenatal pravastatin treatment on altered fetal programming of postnatal growth and metabolic function in a preeclampsia-like murine model

机译：子痫前期小鼠模型中产前普伐他汀治疗对胎儿编程改变产后生长和代谢功能的影响

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摘要

Preeclampsia alters fetal programming and results in long-term metabolic consequences in the offspring. Pravastatin has been shown to prevent preeclampsia in animal models. Our aim was to characterize the effects of preeclampsia on fetal programming of adult growth and metabolic function, and evaluate the role of preventive pravastatin therapy, using a well characterized murine model.STUDY DESIGN: CD-1 mice were injected through the tail vein with adenovirus carrying soluble fms-like tyrosine kinase 1 (sFlt-1) and randomly allocated to pravastatin (5 mg/kg/day; sFlt-1/prav, n = 7) or water (sFit-1, n = 6) until weaning. A control group was injected with adenovirus carrying the murine immunoglobulin G2alpha Fc fragment (mFc, n = 8). Male and female offspring (6-8/group) were weighed every month until 6 months of age. Intraperitoneal glucose tolerance testing was performed after 16 hours of fasting at 3 and 6 months of age; glucose and insulin responses were measured. RESULTS: sFlt-1 offspring weight was lower than mFc control (P < .001) until 2 months of age for females and 5 months of. age for males (P < .001). There were no differences in postnatal growth between mFc and sFlt-1/prav offspring. At 3 and 6 months, female sFlt-1 offspring had higher glucose response compared with mFc and sFlt-1/prav. Three-month-old male sFlt-1 had lower insulin response compared with mFc offspring.
机译：子痫前症会改变胎儿的程序并导致后代的长期代谢后果。普伐他汀在动物模型中已显示可预防先兆子痫。我们的目的是使用特征明确的鼠模型表征先兆子痫对胎儿编程的成年生长和代谢功能的影响，并评估预防性普伐他汀治疗的作用。研究设计：CD-1小鼠经尾静脉注射腺病毒携带可溶性fms样酪氨酸激酶1（sFlt-1），并随机分配给普伐他汀（5 mg / kg /天; sFlt-1 / prav，n = 7）或水（sFit-1，n = 6），直到断奶。对照组注射带有鼠免疫球蛋白G2αFc片段（mFc，n ＝ 8）的腺病毒。每月称雄雄性和雌性后代（6-8只/组），直到6个月大为止。在3和6个月大的孩子禁食16小时后进行腹膜内葡萄糖耐量测试;测量葡萄糖和胰岛素反应。结果：直到2个月大的雌性和5个月大的雌性，sFlt-1的后代体重均低于mFc对照（P <.001）。男性年龄（P <.001）。 mFc和sFlt-1 / prav后代之间的出生后生长无差异。在3和6个月时，雌性sFlt-1后代的葡萄糖反应高于mFc和sFlt-1 / prav。与mFc后代相比，三个月大的雄性sFlt-1具有较低的胰岛素反应。

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