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首页> 外文期刊>American Journal of Obstetrics and Gynecology >Misoprostol for intrauterine device insertion in nulliparous women: A randomized controlled trial
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Misoprostol for intrauterine device insertion in nulliparous women: A randomized controlled trial

机译：米索前列醇用于未产妇子宫内器械插入的随机对照试验

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Objective To examine the effects of preprocedure misoprostol on intrauterine device (IUD) placement in nulliparous women. Study Design In this randomized controlled double-blind trial at the University of New Mexico reproductive health clinic, nulliparous women requesting an IUD were randomized to 400 mcg of buccal misoprostol or placebo 2-8 hours before insertion. Primary outcomes included pain on a 10-cm visual analog scale and women's perception of the value of delaying insertion for an effective medication. Provider ease of insertion and need for adjunctive insertion measures were also assessed, on a visual analog scale. Participants indicated maximum pain after IUD insertion, pain level they would tolerate to avoid delay in IUD insertion, and preference for IUD insertion without delay if an effective medication was available. Results Of 85 women enrolled, 3 were ineligible; 42 were randomized to misoprostol and 40 to placebo. There were no differences between groups in worst insertion pain, (5.8 ± 2.0 vs 5.9 ± 2.0, P =.94), provider ease of insertion (2.2 ± 2.2 vs 2.5 ± 2.2; P =.54) or adjunctive measures (14% vs 25%; P =.27). The groups were willing to tolerate the same mean pain (4.9 ± 2.5 vs 5.7 ± 2.4, P =.18) to avoid waiting for medication. The majority of women (85%) preferred to wait for an effective medication. Conclusion Misoprostol for nulliparous women did not decrease pain or improve the ease of insertion of an IUD. Most women were willing to wait for a medication that decreases pain, indicating a need to pursue alternatives for pain control with IUD insertion.
机译：目的探讨术前米索前列醇对未生育妇女宫内节育器（IUD）放置的影响。研究设计在新墨西哥州大学生殖健康诊所的一项随机对照双盲试验中，要求宫内节育器的未产妇在插入前2-8小时随机分配至400 mcg颊米索前列醇或安慰剂。主要结局包括10厘米视觉模拟评分上的疼痛以及女性对延迟插入有效药物的价值的感知。还以视觉模拟量表评估了服务提供者的插入便利性和辅助插入措施的必要性。参与者指出了放置宫内节育器后的最大疼痛感，为避免延迟放置宫内节育器而可以忍受的疼痛程度，以及在有有效药物的情况下优先选择宫内节育器。结果登记的85名妇女中有3名不符合条件。 42随机分配给米索前列醇，40随机分配给安慰剂。两组之间在最严重的插入疼痛方面（5.8±2.0 vs 5.9±2.0，P = 0.94），提供者易于插入（2.2±2.2 vs 2.5±2.2; P = .54）或辅助措施（14％）没有差异。 vs 25％; P = 0.27）。这些组愿意忍受相同的平均疼痛（4.9±2.5 vs 5.7±2.4，P = .18），以避免等待药物治疗。大多数女性（85％）倾向于等待有效的药物治疗。结论米索前列醇对未生育妇女没有减轻疼痛或改善宫内节育器插入的便利性。大多数妇女愿意等待减轻疼痛的药物治疗，这表明需要为插入IUD进行疼痛控制寻求替代方法。

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