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首页> 外文期刊>American journal of primatology >Preclinical Laboratory Assessments of Predictors of Social Rank in Female Cynomolgus Monkeys
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Preclinical Laboratory Assessments of Predictors of Social Rank in Female Cynomolgus Monkeys

机译：食蟹猕猴社会等级预测因子的临床前实验室评估

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Physiological and behavioral differences between dominant and subordinate monkeys have been useful in preclinical models investigating numerous disease states. In captivity, it has been inferred that subordinate monkeys live in a context of chronic social stress and may be at risk for a variety of dysfunctions; however, the factors that influence eventual rank are not entirely known. The goal of the present study was to first evaluate several phenotypic characteristics as potential trait markers for eventual social rank and then to determine the consequences of social hierarchy on these measures (i.e., state markers). Baseline estradiol, progesterone, cortisol and testosterone concentrations were obtained from 16 pair-housed female cynomolgus monkeys before and after introduction into new social groups (n = 4/group). Furthermore, effects of the initial week of social rank establishment on outcome measures of cognitive performance and homecage activity were examined. Baseline body weight and mean serum estradiol concentrations were the only statistically significant predictors of eventual rank, with future subordinate monkeys weighing less and having higher estradiol concentrations. During initial hierarchy establishment, future subordinate monkeys had increased morning and afternoon cortisol concentrations, increased locomotor activity and impaired cognitive performance on a working memory task. After 3 months of social housing, subordinate monkeys had blunted circulating estradiol and progesterone concentrations. These findings demonstrate differential effects on gonadal hormones and cortisol as a function of social context in normally cycling female monkeys. Furthermore, disruptions in cognitive performance were associated with subordinate status, suggesting strong face validity of this model to the study of factors related to the etiology and treatment of human diseases associated with chronic stress. (C) 2015 Wiley Periodicals, Inc.
机译：在研究许多疾病状态的临床前模型中，优势猴子和从属猴子之间的生理和行为差异已经很有用。在圈养中，据推断，下属猴子生活在长期的社会压力下，可能面临各种功能障碍的危险;但是，影响最终排名的因素尚不完全清楚。本研究的目的是首先评估几种表型特征，作为最终社会等级的潜在特征标记，然后确定社会等级制度对这些措施的影响（即状态标记）。在引入新的社会群体之前和之后，从16对成对的雌性食蟹猕猴中获得基线雌二醇，孕酮，皮质醇和睾丸激素的浓度（n = 4 /组）。此外，检查了社交等级建立的最初一周对认知表现和家庭活动的结果指标的影响。基线体重和平均血清雌二醇浓度是最终等级的唯一统计学上显着的预测因子，未来的下属猴子体重更轻，雌二醇浓度更高。在最初的等级建立过程中，未来的下属猴子在工作记忆任务中早晨和下午皮质醇浓度增加，运动能力增强和认知能力受损。经过3个月的社会安置，下属猴子的循环雌二醇和孕酮浓度降低。这些发现表明，在正常骑行的雌性猴子中，对性腺激素和皮质醇的影响随社交环境的变化而变化。此外，认知能力的破坏与从属地位有关，这表明该模型对于研究与慢性应激相关的人类疾病的病因和治疗有关的因素具有较强的面部有效性。 （C）2015年Wiley Periodicals，Inc.

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