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首页> 外文期刊>American journal of primatology >Progesterone, but not luteal estrogen, is required for the establishment of pregnancy in the new world monkey Cebus apella
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Progesterone, but not luteal estrogen, is required for the establishment of pregnancy in the new world monkey Cebus apella

机译：在新世界猴Cebus apella中建立妊娠需要孕酮而不是黄体雌激素

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The aim of this study was to examine the requirement of luteal progesterone or luteal estrogen for the establishment of pregnancy in the Cebus monkey and to test in a primate species the synergism between RU 486 and letrozole (LTZ) found in rodents for inhibiting implantation. Exposure of target tissues to either hormone was suppressed during the mid-luteal phase of mating cycles by subcutaneous administration of the antiprogestin (RU 486), the aromatase inhibitor LTZ or the antiestrogen (ICI 182780) on days 4-7 of the luteal phase. Administration of 0.1 or 0.5 mg/kg of LTZ on days 5-7 of the luteal phase caused a profound drop in the levels of E-2 in all animals, whereas administration of ICI 182780 0.2 mg/kg on days 4-6 of the luteal phase had the opposite effect. The pregnancy rate in vehicle treated cycles of the same females was (58.3%). Treatment with RU 486, 0.8 mg/kg/day on days 5-7 of the luteal phase-induced endometrial bleeding in 3/5 mated females none of which became pregnant, whereas pregnancy was confirmed in one of the two animals that did not bled. Treatment with RU 486, 0.4 mg/kg/day alone or with LTZ on days 5-7 or ICI 182780 alone, on days 4-6 of the luteal phase failed to induce bleeding, allowing the establishment of pregnancy in 50.0-66.6% of the animals in these groups. We conclude that in Cebus monkeys, progesterone but not luteal estradiol is required for the establishment of pregnancy and that RU 486 and LTZ do not exhibit in this species the synergism found in rodents.
机译：这项研究的目的是检验在Cebus猴子中建立黄体孕酮或黄体雌激素对怀孕的需求，并在灵长类动物中测试RU 486和在啮齿动物中发现的来曲唑（LTZ）之间的协同作用以抑制植入。在黄体期的第4-7天通过皮下注射抗孕激素（RU 486），芳香化酶抑制剂LTZ或抗雌激素（ICI 182780）在交配周期的黄体中期中抑制靶组织暴露于任何一种激素。在黄体期的第5-7天施用0.1或0.5 mg / kg的LTZ会导致所有动物的E-2水平大大下降，而在ICI 182780的第4-6天施用ITZ 182780 0.2 mg / kg黄体期有相反的作用。同一女性在接受车辆治疗的周期中的怀孕率为（58.3％）。在3/5交配的雌性动物中，在5-7天的黄体期诱发的子宫内膜出血中使用RU 486进行治疗，剂量为0.8 mg / kg /天，均未怀孕，而在两只没有出血的动物中证实了怀孕。在黄体期第4-6天单独使用RU 486（0.4 mg / kg /天）或仅在5-7天使用LTZ或仅在ICI 182780上进行治疗，在黄体期第4-6天未能引起出血，从而使50.0-66.6％的孕妇能够确定妊娠这些组中的动物。我们得出的结论是，在Cebus猴子中，孕期需要孕酮而不是黄体雌二醇，并且RU 486和LTZ在该物种中不表现出在啮齿动物中发现的协同作用。

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