• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American journal of psychiatry >Psychiatric disorders in preschool offspring of parents with bipolar disorder: the Pittsburgh Bipolar Offspring Study (BIOS).
【24h】

Psychiatric disorders in preschool offspring of parents with bipolar disorder: the Pittsburgh Bipolar Offspring Study (BIOS).

机译：患有双相情感障碍的父母的学龄前儿童的精神疾病：匹兹堡双相情感后代研究（BIOS）。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: The authors evaluated lifetime prevalence and specificity of DSM-IV psychiatric disorders and severity of depressive and manic symptoms at intake in preschool offspring of parents with bipolar I and II disorders. METHOD: A total of 121 offspring ages 2-5 years from 83 parents with bipolar disorder and 102 offspring of 65 demographically matched comparison parents (29 with non-bipolar psychiatric disorders and 36 without any lifetime psychopathology) were recruited for the study. Parents with bipolar disorder were recruited through advertisements and adult outpatient clinics, and comparison parents were ascertained at random from the community. Participants were evaluated with standardized instruments. All staff were blind to parental diagnoses. RESULTS: After adjustment for within-family correlations and both biological parents' non-bipolar psychopathology, offspring of parents with bipolar disorder, particularly those older than age 4, showed an eightfold greater lifetime prevalence of attention deficit hyperactivity disorder (ADHD) and significantly higher rates of having two or more psychiatric disorders compared to the offspring of the comparison parents. While only three offspring of parents with bipolar disorder had mood disorders, offspring of parents with bipolar disorder, especially those with ADHD and oppositional defiant disorder, had significantly more severe current manic and depressive symptoms than comparison offspring. CONCLUSIONS: Preschool offspring of parents with bipolar disorder have an elevated risk for ADHD and have greater levels of subthreshold manic and depressive symptoms than children of comparison parents. Longitudinal follow-up is warranted to evaluate whether these children are at high risk for developing mood and other psychiatric disorders.
机译：目的：作者评估了患有双相I和II型双相情感障碍父母的学龄前儿童的DSM-IV精神障碍的终生患病率和特异性以及摄入时抑郁和躁狂症状的严重程度。方法：本研究共招募了83名双相情感障碍父母的121个2-5岁的后代，以及65个在人口统计学上相匹配的比较父母中的102个后代（29位非双相情感障碍和36位无终生精神病学）。通过广告和成人门诊诊所招募双相情感障碍的父母，并从社区中随机确定比较父母。参与者用标准化工具进行评估。所有工作人员都无法接受父母的诊断。结果：在调整了家庭内部的相关性以及两个亲生父母的非双相心理病理学之后，双相情感障碍的父母，尤其是那些年龄大于4岁的父母，其后代的注意力缺陷多动障碍（ADHD）的终生患病率增加了八倍，并且明显更高与比较父母的后代相比有两种或更多种精神疾病的发生率患有双相情感障碍的父母中只有三个后代患有情绪障碍，而患有双相情感障碍的父母（尤其是患有ADHD和对立反抗性障碍的父母）的后代当前的躁狂和抑郁症状要比比较后代严重得多。结论：双相情感障碍父母的学龄后代患ADHD的风险较高，并且低于比较父母子女的阈下躁狂和抑郁症状水平。纵向随访是必要的，以评估这些儿童是否有发展情绪和其他精神疾病的高风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号