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Thresholds for food allergens and their value to different stakeholders.

机译：食物过敏原的阈值及其对不同利益相关者的价值。

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摘要

Thresholds constitute a critical piece of information in assessing the risk from allergenic foods at both the individual and population levels. Knowledge of the minimum dose that can elicit a reaction is of great interest to all food allergy stakeholders. For allergic individuals and health professionals, individual threshold data can inform allergy management. Population thresholds can help both the food industry and regulatory authorities assess the public health risk and design appropriate food safety objectives to guide risk management. Considerable experience has been gained with the double-blind placebo-controlled food challenge (DBPCFC), but only recently has the technique been adapted to provide data on thresholds. Available data thus vary greatly in quality, with relatively few studies providing the best quality individual data, using the low-dose DBPCFC. Such high quality individual data also form the foundation for population thresholds, but these also require, in addition to an adequate sample size, a good characterization of the tested population in relation to the whole allergic population. Determination of thresholds at both an individual level and at a population level is influenced by many factors. This review describes a low-dose challenge protocol developed as part of the European Community-funded Integrated Project Europrevall, and strongly recommends its wider use so that data are generated that can readily increase the power of existing studies.
机译：阈值是评估个人和人群中过敏性食品风险的关键信息。所有食物过敏的利益相关者都对引起反应的最小剂量的知识非常感兴趣。对于过敏的个人和卫生专业人员，个人阈值数据可以告知过敏管理。人口阈值可以帮助食品行业和监管机构评估公共健康风险，并设计适当的食品安全目标来指导风险管理。使用双盲安慰剂对照食物试验（DBPCFC）已经获得了相当多的经验，但是直到最近才对该技术进行了修改，以提供阈值数据。因此，可用数据的质量差异很大，使用低剂量DBPCFC进行的研究提供最佳质量的单个数据的研究相对较少。这种高质量的个人数据也构成了人口阈值的基础，但是，除了足够的样本量外，还需要对整个过敏性人群的测试人群进行良好的表征。在个人层面和总体层面上确定阈值受许多因素影响。这篇评论描述了作为欧洲共同体资助的综合项目Europrevall的一部分开发的低剂量挑战规程，并强烈建议将其更广泛地使用，以便生成可以轻易增加现有研究能力的数据。

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