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首页> 外文期刊>Allergy >Sinonasal pathology in nonallergic asthma and COPD: 'united airway disease' beyond the scope of allergy.
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Sinonasal pathology in nonallergic asthma and COPD: 'united airway disease' beyond the scope of allergy.

机译：非过敏性哮喘和COPD的鼻腔病理：“联合气道疾病”超出了过敏范围。

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BACKGROUND: In contrast to the epidemiological and clinical association between allergic rhinitis and asthma, upper airway inflammation is less characterized in patients with nonatopic asthma and virtually unexplored in chronic obstructive pulmonary disease (COPD). Here, sinonasal pathology is studied in patients with allergic asthma, nonallergic asthma and COPD. METHODS: Ninety patients with stable bronchial disease were included in the study, of which 35 were diagnosed with allergic asthma, 24 with nonallergic asthma and 31 with COPD. Concurrently, 61 control subjects without pulmonary disease were included and matched for age and smoking habits respectively with the asthma and the COPD group. Sinonasal symptoms were evaluated on a visual analogue scale and rhinosinusitis-related impairment of quality of life was assessed with the sino-nasal outcome test-22 (SNOT-22) questionnaire. Nasal mucosal abnormalities were quantified with nasal endoscopy and nasal secretions collected for measuring inflammatory mediators. RESULTS: Allergic asthmatics, nonallergic asthmatics and COPD patients reported more nasal symptoms than their respective control subjects, had a higher SNOT-22 score and presented more mucosal abnormalities in the nose. Nasal secretions of both allergic and nonallergic asthmatics contained higher levels of eotaxin, G-CSF, IFN-gamma and MCP-1 than controls. Allergic asthmatics had higher nasal IP-10 levels as well. COPD-patients had higher nasal levels of eotaxin, G-CSF and IFN-gamma than controls. CONCLUSION: Patients with allergic and nonallergic asthma and COPD show increased nasal symptoms and more nasal inflammation. Hence, our data confirm the 'united airways' concept to be beyond the scope of allergic asthma.
机译：背景：与变应性鼻炎和哮喘之间的流行病学和临床关联相反，非特应性哮喘患者的上呼吸道炎症特征较少，而在慢性阻塞性肺疾病（COPD）中则几乎没有发现。在这里，对过敏性哮喘，非过敏性哮喘和COPD患者进行鼻窦病理学研究。方法：本研究纳入了90例稳定的支气管疾病患者，其中35例被诊断为过敏性哮喘，24例为非过敏性哮喘，31例为COPD。同时，纳入61例无肺部疾病的对照受试者，并根据年龄和吸烟习惯将其与哮喘和COPD组相匹配。以视觉模拟量表评估鼻鼻症状，并通过鼻-鼻结局测试22（SNOT-22）问卷评估与鼻-鼻窦炎相关的生活质量损害。通过鼻内窥镜检查定量鼻粘膜异常，并收集鼻分泌物以测量炎性介质。结果：过敏性哮喘，非过敏性哮喘和COPD患者比各自的对照组受试者报告更多的鼻部症状，SNOT-22评分更高，并且鼻粘膜异常更多。过敏性和非过敏性哮喘患者的鼻分泌物中的嗜酸性粒细胞趋化因子，G-CSF，IFN-γ和MCP-1含量均高于对照组。过敏性哮喘患者的鼻IP-10水平也较高。 COPD患者的鼻中嗜酸性粒细胞趋化因子，G-CSF和IFN-γ水平高于对照组。结论：过敏性和非过敏性哮喘及COPD患者表现出鼻腔症状增加和鼻腔炎症增加。因此，我们的数据证实“联合气道”的概念超出了过敏性哮喘的范围。

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