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首页> 外文期刊>Allergy >Neuropsychologic status at the age 4 years and atopy in a population-based birth cohort.
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Neuropsychologic status at the age 4 years and atopy in a population-based birth cohort.

机译：基于人群的出生队列中4岁及特应性过敏的神经心理状态。

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BACKGROUND: Mental health has been reported to be associated with allergy, but only a few cohort studies have assessed if neurodevelopment predicts atopy. OBJECTIVE: To investigate if neurobehavioral status of healthy 4-year-old children was associated with specific immunoglobulin E (IgE) at the same age and skin prick test results 2 years later. METHODS: A population-based birth cohort enrolled 482 children, 422 of them (87%) provided neurobehavioral data, 341 (71%) had specific IgE measured at the age of 4 years; and 395 (82%) had skin prick tests completed at the age of 6 years. Atopy was defined as IgE levels higher than 0.35 kU/l to any of the three tested allergens at the age of 4 or as a positive skin prick test to any of the six tested allergens at the age of 6. McCarthy Scales of Child Abilities and California Preschool Social Competence Scale were the psychometric instruments used. RESULTS: Twelve percent of children at the age of 4 and 17% at the age of 6 were atopic. Neurobehavioral scores were negatively associated with 6-year-old atopy after adjustment for socio-demographic and allergic factors, A relative risk of 3.06 (95% CI: 1.30-7.24) was associated with the lowest tertile (scorings < or =90 points) of the general cognitive scale. Similar results were found for verbal abilities, executive functions, and social competence. Asthma, wheezing, rhinitis, and eczema at the age of 6, but not at the age of 4, were associated with neurodevelopment at the age of 4. CONCLUSIONS: Neuropsychologic functioning and later atopy are negatively associated in preschool age children.
机译：背景：据报道心理健康与过敏有关，但只有少数队列研究评估了神经发育是否预示着特应性。目的：调查健康的4岁儿童在相同年龄时的神经行为状态是否与特异性免疫球蛋白E（IgE）相关，并在2年后进行皮肤点刺测试。方法：以人口为基础的出生队列纳入了482名儿童，其中422名（87％）提供了神经行为学数据，341名（71％）在4岁时进行了特异性IgE的检测。 395名（82％）在6岁时完成了皮肤点刺测试。特应性被定义为在4岁时对三种被测过敏原中的任何一种的IgE水平高于0.35 kU / l，或在6岁时对六种被测过敏原中的任何一种的阳性皮肤点刺试验。加州学龄前社会能力量表是所使用的心理计量工具。结果：4％的儿童中有12％发生过敏性反应，而6岁的儿童中有17％。在调整了社会人口统计学和过敏因素后，神经行为评分与6岁特应性反应呈负相关。最低三分位数（得分<或= 90分）与相对危险度3.06（95％CI：1.30-7.24）相关。一般认知量表。在言语能力，执行功能和社会能力方面也发现了类似的结果。 6岁时哮喘，喘息，鼻炎和湿疹在4岁时与4岁时的神经发育相关，但在4岁时则与神经发育无关。结论：学龄前儿童的神经心理学功能和后来的特应性呈负相关。

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