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首页> 外文期刊>Allergy >GA(2)LEN skin test study II: clinical relevance of inhalant allergen sensitizations in Europe.
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GA(2)LEN skin test study II: clinical relevance of inhalant allergen sensitizations in Europe.

机译：GA（2）LEN皮肤试验研究II：在欧洲，吸入性过敏原致敏的临床意义。

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BACKGROUND: Skin prick testing is the standard for diagnosing IgE-mediated allergies. A positive skin prick reaction, however, does not always correlate with clinical symptoms. A large database from a Global Asthma and Allergy European Network (GA(2)LEN) study with data on clinical relevance was used to determine the clinical relevance of sensitizations against the 18 most frequent inhalant allergens in Europe. The study population consisted of patients referred to one of the 17 allergy centres in 14 European countries (n = 3034, median age = 33 years). The aim of the study was to assess the clinical relevance of positive skin prick test reactions against inhalant allergens considering the predominating type of symptoms in a pan-European population of patients presenting with suspected allergic disease. METHODS: Clinical relevance of skin prick tests was recorded with regard to patient history and optional additional tests. A putative correlation between sensitization and allergic disease was assessed using logistic regression analysis. RESULTS: While an overall rate of >or=60% clinically relevant sensitizations was observed in all countries, a differential distribution of clinically relevant sensitizations was demonstrated depending on type of allergen and country where the prick test was performed. Furthermore, a significant correlation between the presence of allergic disease and the number of sensitizations was demonstrated. CONCLUSION: This study strongly emphasizes the importance of evaluating the clinical relevance of positive skin prick tests and calls for further studies, which may, ultimately, help increase the positive predictive value of allergy testing.
机译：背景：皮肤点刺测试是诊断IgE介导的过敏的标准。但是，阳性的皮肤刺痛反应并不总是与临床症状相关。来自全球哮喘和过敏欧洲网络（GA（2）LEN）研究的大型数据库及其临床相关数据用于确定针对欧洲18种最常见的吸入性过敏原的致敏作用的临床相关性。研究人群包括转诊到14个欧洲国家的17个过敏中心之一的患者（n = 3034，中位年龄= 33岁）。该研究的目的是评估在考虑到可疑过敏性疾病的泛欧洲患者中症状的主要类型，针对吸入性变应原的阳性皮肤点刺试验反应的临床相关性。方法：记录有关患者病史和可选附加检查的皮肤点刺试验的临床相关性。使用逻辑回归分析评估了致敏性和过敏性疾病之间的假定相关性。结果：尽管在所有国家中观察到的临床相关致敏性总发生率均大于或等于60％，但根据变应原的类型和进行点刺试验的国家，临床上相关致敏性的分布却有所不同。此外，证实了过敏性疾病的存在与致敏次数之间的显着相关性。结论：本研究强烈强调评估阳性皮肤点刺试验的临床相关性的重要性，并呼吁进行进一步研究，这最终可能有助于增加变态反应试验的阳性预测价值。

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