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Grading quality of evidence and strength of recommendations in clinical practice guidelines.

机译：分级的证据质量和临床实践指南中建议的强度。

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The GRADE (Grades of Recommendation, Assessment, Development, and Evaluation) approach provides guidance to grading the quality of underlying evidence and the strength of recommendations in health care. The GRADE system's conceptual underpinnings allow for a detailed stepwise process that defines what role the quality of the available evidence plays in the development of health care recommendations. The merit of GRADE is not that it eliminates judgments or disagreements about evidence and recommendations, but rather that it makes them transparent. This first article in a three-part series describes the GRADE framework in relation to grading the quality of evidence about interventions based on examples from the field of allergy and asthma. In the GRADE system, the quality of evidence reflects the extent to which a guideline panel's confidence in an estimate of the effect is adequate to support a particular recommendation. The system classifies quality of evidence as high, moderate, low, or very low according to factors that include the study methodology, consistency and precision of the results, and directness of the evidence.
机译：GRADE（建议，评估，开发和评估的等级）方法为分级基础证据的质量和建议在医疗保健中的强度提供了指导。 GRADE系统的概念基础允许一个详细的逐步过程，该过程定义了可用证据的质量在卫生保健建议制定中所起的作用。 GRADE的优点不是消除对证据和建议的判断或分歧，而是使其透明化。这个由三部分组成的系列文章中的第一篇文章介绍了GRADE框架，该框架基于过敏和哮喘领域的实例，对干预证据的质量进行了分级。在GRADE系统中，证据的质量反映了指导小组对效果评估的信心足以支持特定建议的程度。系统根据包括研究方法，结果的一致性和准确性以及证据的直接性在内的因素将证据的质量分为高，中，低或非常低。

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