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首页> 外文期刊>Allergy >Monitoring adherence to beclomethasone in asthmatic children and adolescents through four different methods.
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Monitoring adherence to beclomethasone in asthmatic children and adolescents through four different methods.

机译：通过四种不同的方法监测哮喘儿童和青少年对倍氯米松的依从性。

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BACKGROUND: Suboptimal adherence to inhaled steroids is a known problem in children and adolescents, even when medications are administered under parental supervision. This study aimed to verify the adherence rate to beclomethasone dipropionate (BDP) by four currently available methods. METHODS: In this concurrent cohort study, 102 randomly selected asthmatic children and adolescents aged 3-14 years were followed for 12 months. Adherence rate was assessed every 2 months by self and/or parent report, pharmacy dispensing data, electronic device (Doser); Meditrack Products, Hudson, MA, USA) monitor, and canister weight. RESULTS: Mean adherence rates to BDP by self and/or parent report, pharmacy records, Doser, and canister weight were 97.9% (95% CI 88.0-98.6), 70.0% (95% CI 67.6-72.4), 51.5% (95% CI 48.3-54.6), and 46.3% (95% CI 44.1-48.4), respectively. Agreement analysis between (Doser) and canister weight revealed a weighted kappa equal to 0.76 (95% CI 0.65-0.87). CONCLUSIONS: Adherence was a dynamic event and rates decreased progressively for all methods over the 12-month follow-up. Canister weight and electronic monitoring measures were more accurate than self/parent reports and pharmacy records. Rates obtained by these two methods were very close and statistical analysis also showed a substantial agreement between them. As measurements by canister weight are less costly compared with currently available electronic devices, it should be considered as an alternative method to assess adherence in both clinical research and practice.
机译：背景：即使在父母的监督下服用药物，对吸入类固醇的最佳依从性仍是儿童和青少年的已知问题。这项研究旨在通过四种当前可用的方法来验证对倍氯米松二丙酸酯（BDP）的依从性。方法：在这项同期队列研究中，对102名3-14岁的哮喘儿童和青少年进行了为期12个月的随访。每两个月通过自我和/或家长报告，药房分配数据，电子设备（剂量分析仪）评估依从率; Meditrack Products，美国马萨诸塞州哈德逊市）显示器和药罐重量。结果：通过自我和/或父母报告，药房记录，剂量与剂量和罐重量对BDP的平均依从率分别为97.9％（95％CI 88.0-98.6），70.0％（95％CI 67.6-72.4），51.5％（95）百分比CI 48.3-54.6）和46.3％（95％CI 44.1-48.4）。 （加料器）与罐重量之间的一致性分析表明，加权卡伯值等于0.76（95％CI 0.65-0.87）。结论：在12个月的随访中，所有方法的依从性是一个动态事件，发生率逐渐降低。罐的重量和电子监控措施比自我/父母报告和药房记录更准确。通过这两种方法获得的比率非常接近，并且统计分析也显示出它们之间的实质一致性。由于与现有的电子设备相比，通过罐体重量进行测量的成本较低，因此应将其视为评估临床研究和实践中依从性的替代方法。

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