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Objective assessments of allergic and nonallergic rhinitis in young children.

机译：对幼儿过敏性和非过敏性鼻炎的客观评估。

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BACKGROUND: Allergic and nonallergic rhinitis are common childhood disorders. OBJECTIVE: To study nasal eosinophilia and nasal airway patency in young children with allergic and nonallergic rhinitis to assess the pathology behind such diagnoses. METHODS: We investigated 255 children at six years of age from the Copenhagen Prospective Study on Asthma in Childhood birth cohort assessing rhinitis history, specific immunoglobulin E relevant to rhinitis symptoms, nasal eosinophilia and nasal airway patency by acoustic rhinometry before and after decongestion. Associations were studied in a multivariate graphical model corrected for gender, height and nasal steroid usage. RESULTS: Allergic rhinitis was significantly and directly associated with irreversible nasal airway obstruction (reduced decongested nasal airway patency) (P = 0.004), whereas nonallergic rhinitis was not. Both allergic rhinitis (P = 0.000) and nonallergic rhinitis (P = 0.014) were directly and significantly associated with nasal eosinophilia, but this association was stronger for allergic rhinitis. CONCLUSION: Allergic rhinitis and nonallergic rhinitis are of different pathologies as suggested from their different associations not only to allergy but importantly also to irreversible nasal airway obstruction and eosinophilic inflammation. Allergic rhinitis was significantly associated with nasal eosinophilia and irreversible nasal airway obstruction suggesting chronic inflammation and structural remodeling of the nasal mucosa in children at the age of 6 years. Nonallergic rhinitis exhibited no change in the nasal airway patency, but some nasal mucosal eosinophilia albeit less than children with allergic rhinitis.
机译：背景：过敏性和非过敏性鼻炎是常见的儿童疾病。目的：研究过敏和非过敏性鼻炎幼儿的鼻嗜酸性粒细胞增多和鼻气道通畅性，以评估此类诊断的病理学。方法：我们从哥本哈根儿童出生队列前瞻性研究队列中对255名6岁的儿童进行了调查，以评估其在充血之前和之后的鼻炎病史，与鼻炎症状相关的特定免疫球蛋白E，鼻嗜酸性粒细胞增多和鼻气道通畅性。在针对性别，身高和鼻类固醇使用量校正的多元图形模型中研究了关联。结果：过敏性鼻炎与不可逆的鼻气道阻塞显着且直接相关（减少的鼻气道充血减少）（P = 0.004），而非过敏性鼻炎则没有。变应性鼻炎（P = 0.000）和非变应性鼻炎（P = 0.014）均与鼻嗜酸性粒细胞增多直接相关，但与变应性鼻炎相关性更强。结论：过敏性鼻炎和非过敏性鼻炎的病理不同，不仅与变态反应有关，而且对不可逆转的鼻气道阻塞和嗜酸性粒细胞炎症也很重要。变应性鼻炎与鼻嗜酸性粒细胞增多和不可逆的鼻气道阻塞显着相关，这表明6岁儿童的慢性炎症和鼻黏膜结构重塑。非过敏性鼻炎的鼻气道通畅性没有变化，但是一些鼻粘膜嗜酸性粒细胞增多症尽管比过敏性鼻炎的儿童少。

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