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Does asthma control correlate with quality of life related to upper and lower airways? A real life study.

机译：哮喘控制与上呼吸道和下呼吸道的生活质量相关吗？现实生活中的研究。

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BACKGROUND: The goal of asthma therapy is to achieve an optimal level of disease control, but the relationship between asthma control, impact of comorbid rhinitis and health related quality of life (HRQoL) in real life remains unexplored. OBJECTIVE: The aims of this real life study were to evaluate asthma control, the impact of asthma (with and without rhinitis) on HRQoL, the relationship between asthma control and HRQoL, and the role of rhinitis on asthma control and HRQoL. METHODS: 122 asthma patients completed the Asthma Control Test, Rhinitis Symptoms score (T5SS) and RHINASTHMA. RESULTS: Asthma control was unsatisfactory (44.27% of uncontrolled patients), as well as HRQoL. Controlled patients controlled showed significantly lower scores in all the RHINASTHMA domains compared to uncontrolled. Irrespective of their level of control, patients with rhinitis symptoms showed worse HRQoL in Upper Airways (UA) (P < 0.0001), Lower Airways (LA) (P < 0.001), and Global Summary (GS) (P < 0.0001). In patients with symptomatic rhinitis, RHINASTHMA were lower in controlled asthma patients (UA P = 0.002; LA P < 0.0001; RAI P < 0.01; GS P < 0.0001). Asthma control was associated with lower T5SS score (P = 0.034). CONCLUSION: Asthma control in real life is unsatisfactory. Rhinitis and asthma influence each other in terms of control and HRQoL. The control of rhinitis in asthma patients can lead to an optimization of HRQoL related to the upper airways, while this phenomenon is not so evident in asthma. These results suggest to strengthen the ARIA recommendation that asthma patients must be evaluated for rhinitis and vice versa.
机译：背景：哮喘治疗的目标是达到最佳的疾病控制水平，但在现实生活中，哮喘控制，合并性鼻炎的影响与健康相关的生活质量（HRQoL）之间的关系尚待探索。目的：本真实生活研究的目的是评估哮喘控制，哮喘（有或没有鼻炎）对HRQoL的影响，哮喘控制与HRQoL的关系以及鼻炎在哮喘控制和HRQoL中的作用。方法：122名哮喘患者完成了哮喘控制测试，鼻炎症状评分（T5SS）和RHINASTHMA。结果：哮喘控制和HRQoL均不令人满意（占未控制患者的44.27％）。与非对照相比，对照患者在所有RHINASTHMA域中的得分均明显较低。不论其控制水平如何，有鼻炎症状的患者在上呼吸道（UA）（P <0.0001），下呼吸道（LA）（P <0.001）和总体概要（GS）（P <0.0001）中表现出较差的HRQoL。在有症状的鼻炎患者中，控制性哮喘患者的RHINASTHMA较低（UA P = 0.002; LA P <0.0001; RAI P <0.01; GS P <0.0001）。哮喘控制与较低的T5SS评分相关（P = 0.034）。结论：现实生活中的哮喘控制效果不理想。鼻炎和哮喘在控制和HRQoL方面相互影响。控制哮喘患者的鼻炎可以导致与上呼吸道相关的HRQoL的优化，而这种现象在哮喘中并不十分明显。这些结果表明，ARIA建议必须对哮喘患者进行鼻炎评估，反之亦然。

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