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首页> 外文期刊>Allergy >Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy.
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Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy.

机译：在卡累利阿州，针对CD14和CC16单核苷酸多态性和变态反应的环境基因对立基因。

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BACKGROUND: Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between 'Western' and 'Eastern' environments. OBJECTIVES: We investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women. METHODS: Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C-159T and CC16 A38G. RESULTS: For both CD14 C-159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C-159T, an interactive effect on ever itchy rash (P(interaction) = 0.004), itchy rash <12 mo (P(interaction) = 0.001) and dry cough at night in the past 12 months (<12 months) (P(interaction) = 0.011) was found; the risk allele was C in Russians and T in Finns. For CC16 A38G, an interaction was significant for ever rhinitis (P(interaction) = 0.006), rhinitis <12 mo (P(interaction) = 0.004), and marginally significant for ever hayfever (P(interaction) = 0.07), allergic eye symptoms <12 mo (P(interaction) = 0.09); their risk allele was G in Russians and A in Finns. CONCLUSION: An Eastern vs Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women.
机译：背景：芬兰卡累利阿人的过敏性疾病患病率高于俄罗斯卡累利阿人。由于这两个人口通常都来自同一种族，因此卡累利阿人人口为分析“西方”和“东方”环境之间的遗传和过敏性疾病相互作用提供了独特的机会。目的：我们调查了芬兰和俄罗斯卡累利阿妇女中过敏性疾病与CD14和CC16多态性之间的关联。方法：招募成年雌性卡累利阿人（330名芬兰人和274名俄罗斯人），检查其症状和状况，包括鼻炎，发痒的皮疹，哮喘和特应性，并对CD14 C-159T和CC16 A38G进行基因分型。结果：对于CD14 C-159T和CC16 A38G，芬兰卡累利阿特应性表型的风险等位基因是俄罗斯卡累利阿中的保护性等位基因。对于CD14 C-159T，过去12个月（<12个月）夜间瘙痒性皮疹（P（相互作用）= 0.004），瘙痒性皮疹<12 mo（P（相互作用）= 0.001）和夜间干咳有相互作用。 （P（相互作用）= 0.011）;风险等位基因在俄罗斯人中为C，在芬兰人中为T。对于CC16 A38G，交互作用对于过长的鼻炎（P（交互作用）= 0.006），鼻炎<12 mo（P（交互作用）= 0.004）以及对于花粉过敏（P（交互作用）= 0.07），过敏性眼球均具有显着意义症状<12 mo（P（相互作用）= 0.09）;他们的风险等位基因在俄罗斯人中为G，在芬兰人中为A。结论：东方与西方环境似乎通过相反的等位基因对成年女性发生过敏性疾病的风险产生影响。

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