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首页> 外文期刊>Allergy >Strong allergic patch test reactions may indicate a general disposition for contact allergy.
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Strong allergic patch test reactions may indicate a general disposition for contact allergy.

机译：强烈的过敏斑试验反应可能表明接触过敏的一般性倾向。

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Background: Patch test patients have two or more positive reactions to unrelated allergens more often than to be expected by chance. This study evaluates synchronous patch test reactions to test the hypothesis that in such cases an allergen-independent disposition for contact sensitization may be involved. Methods: Data of 87 834 patients tested with a standard patch test series in 42 centers of a Central European Network were retrospectively evaluated. Analyses were done for synchronous positive reactions of graded strength to nickel sulfate, fragrance mix, and to those five allergens that followed in frequency of positive results. All seven allergens selected were not related by chemical structure or exposure. Descriptive univariate and bivariate analyses as well as a polytomous logistic regression analysis were performed. Odds ratios with 95% confidence intervals were calculated. Results: With an increasing strength of a positive reaction to nickel or to fragrance mix the likelihood of further positive reactions to unrelated contact allergens increased significantly, and the mean strength of such additional reactions raised steadily with an increasing strength of a nickel or fragrance reaction. Conclusions: Our findings support the idea that patients who respond with a strong patch test reaction may have a particular general disposition to acquire contact sensitivity to additional unrelated allergens. They should therefore not only be advised to avoid their known allergen but in addition to minimize exposure other contact allergens.
机译：背景：斑贴试验患者对无关的过敏原产生两个或更多阳性反应的可能性比偶然预期的要高。这项研究评估了同步斑贴试验的反应，以检验在这种情况下可能涉及与变应原无关的接触敏化的假设。方法：回顾性评估了中欧网络的42个中心使用标准斑贴试验系列测试的87 834名患者的数据。分析了强度梯度对硫酸镍，香料混合物以及随即出现阳性结果的五种过敏原的同步阳性反应。选择的所有七种过敏原均与化学结构或暴露无关。进行了描述性单变量和双变量分析以及多因素逻辑回归分析。计算出置信区间为95％的几率。结果：随着对镍或香料混合物的阳性反应强度的增加，与无关的接触变应原发生进一步阳性反应的可能性显着增加，并且此类附加反应的平均强度随着镍或香料反应强度的增加而稳步提高。结论：我们的发现支持这样的观点，即对斑贴试验反应强烈的患者可能具有特殊的一般性倾向，以获得对其他无关过敏原的接触敏感性。因此，不仅应建议他们避免使用已知的过敏原，而且还应尽量减少接触其他过敏原。

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