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首页> 外文期刊>Allergy >The effect of BDNF gene variants on asthma in German children.
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The effect of BDNF gene variants on asthma in German children.

机译：BDNF基因变异对德国儿童哮喘的影响。

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BACKGROUND: Allergic inflammation can trigger neuronal dysfunction and structural changes in the airways and the skin. Levels of brain-derived neurotrophic factor (BDNF) are strongly up regulated at the location of allergic inflammation. AIM: We systematically investigated whether polymorphisms in the BDNF gene influence the development or severity of asthma and atopic diseases. METHODS: The BDNF gene was screened for mutations in 80 chromosomes. Genotyping of six BDNF tagging polymorphisms was performed in a cross-sectional study population of 3099 children from Dresden and Munich (age 9-11 years, ISAAC II). Furthermore, polymorphisms were also investigated in an additional 655 asthma cases analysed with a random sample of 767 children selected from ISAAC II. Associations were calculated via chi-square test and anova using SAS Genetics and spss. RESULTS: We identified nine polymorphisms with minor allele frequency >or=0.03, one of them leading to an amino acid change from Valine to Methionine. In the cross-sectional study population, no significant association was found with asthma or any atopic disease. However, when more severe asthma cases from the MAGIC study were analysed, significant asthma effects were observed with rs6265 (odds ratio 1.37, 95% confidence interval 1.14-1.64, P = 0.001), rs11030101 (OR 0.82, 95%CI 0.70-0.95, P = 0.009) and rs11030100 (OR 1.19, 95%CI 1.00-1.42, P = 0.05). CONCLUSIONS: As in previous studies, effects of BDNF polymorphisms on asthma remain controversial. The data may suggest that BDNF polymorphisms contribute to severe forms of asthma.
机译：背景：过敏性炎症可引发神经元功能异常以及气道和皮肤的结构变化。脑源性神经营养因子（BDNF）的水平在过敏性炎症的位置强烈上调。目的：我们系统地研究了BDNF基因的多态性是否影响哮喘和特应性疾病的发生或严重程度。方法：筛选BDNF基因中80条染色体的突变。在来自德累斯顿和慕尼黑（年龄9-11岁，ISAAC II）的3099名儿童的横断面研究人群中进行了6种BDNF标签多态性的基因分型。此外，还对另外655例哮喘病例进行了多态性分析，对ISAAC II的767名儿童进行了随机抽样分析。通过卡方检验和使用SAS Genetics和spss的方差分析计算关联。结果：我们鉴定出了9个多态性，其等位基因频率较小或大于或等于0.03，其中一个导致氨基酸从缬氨酸变为蛋氨酸。在横断面研究人群中，未发现与哮喘或任何特应性疾病有显着相关性。但是，当对MAGIC研究中更严重的哮喘病例进行分析时，观察到了显着的哮喘效果：rs6265（比值1.37，95％置信区间1.14-1.64，P = 0.001），rs11030101（OR 0.82，95％CI 0.70-0.95） ，P = 0.009）和rs11030100（OR 1.19，95％CI 1.00-1.42，P = 0.05）。结论：与以前的研究一样，BDNF多态性对哮喘的影响仍存在争议。数据可能表明BDNF多态性导致了严重的哮喘。

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