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首页> 外文期刊>Allergy >Strontium ranelate-induced DRESS syndrome: first two case reports.
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Strontium ranelate-induced DRESS syndrome: first two case reports.

机译：雷奈酸锶诱发的DRESS综合征：前两例报道。

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摘要

We report the two first cases of drug rash with eosinophilia andsystemic symptoms (DRESS) syndrome (1) induced by strontium ranelate, a new drug used to treat osteoporosis.A 78-year-old woman was prescribed strontium ralenate (SR). Ten days later, she developed a febrile, diffuse rash leading to the discontinuation of SR 2 days later and the prescription of prednisone (40 mg/day). She was admitted to hospital 8 days later with a generalized purplish rash, facial oedema and fever. Blood tests showed eosinophilia (7052/ml), hyperbasophilic lymphocytes (164/ml) and liver damage (AST 93 IU/1, ALT 202 IU/1, ALP 215 IU/1, GGT 301 IU/L). Skin biopsy showed a lymphohistiocytic infiltrate, with eosinophilia in the superficial dermis, and bone medulla was infiltrated with eosinophils (28%). Serological tests for hepatitis (B, C) were negative, as were autoantibody tests, blood and urine cultures. On the 18th day, the rash worsened with uveitis thus requiring an increase in the dose of prednisone. Thisled to improvement, but attempts to decrease corticoid dose led to the recurrence of DRESS syndrome.
机译：我们报告了首例由雷奈酸锶（一种用于治疗骨质疏松症的新药）诱发的嗜酸性粒细胞增多和全身症状（DRESS）综合征（1）的皮疹案例。一名78岁的妇女开了雷兰酸锶（SR）。十天后，她出现了发热性弥漫性皮疹，导致2天后停用SR和泼尼松处方（40 mg /天）。 8天后，她因广泛的紫红色皮疹，面部浮肿和发烧入院。血液测试显示嗜酸性粒细胞增多（7052 / ml），嗜碱性淋巴细胞（164 / ml）和肝损伤（AST 93 IU / 1，ALT 202 IU / 1，ALP 215 IU / 1，GGT 301 IU / L）。皮肤活检显示淋巴组织细胞浸润，表层真皮有嗜酸性粒细胞增多，而嗜酸性粒细胞浸润了骨髓质（28％）。肝炎的血清学检查（B，C）为阴性，自身抗体检查，血液和尿液培养也为阴性。在第18天，皮疹因葡萄膜炎而恶化，因此需要增加泼尼松的剂量。这有所改善，但尝试减少皮质激素剂量导致DRESS综合征的复发。

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