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TSLP polymorphisms are associated with asthma in a sex-specific fashion.

机译：TSLP多态性以性别特定的方式与哮喘相关。

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BACKGROUND: Single nucleotide polymorphisms (SNPs) in thymic stromal lymphopoietin (TSLP) have been associated with IgE (in girls) and asthma (in general). We sought to determine whether TSLP SNPs are associated with asthma in a sex-specific fashion. METHODS: We conducted regular and sex-stratified analyses of association between SNPs in TSLP and asthma in families of children with asthma in Costa Rica. Significant findings were replicated in whites and African-American participants in the Childhood Asthma Management Program, in African-Americans in the Genomic Research on Asthma in the African Diaspora study, in whites and Hispanics in the Children's Health Study, and in whites in the Framingham Heart Study (FHS). MAIN RESULTS: Two SNPs in TSLP (rs1837253 and rs2289276) were significantly associated with a reduced risk of asthma in combined analyses of all cohorts (P values of 2 x 10(-5) and 1 x 10(-5) , respectively). In a sex-stratified analysis, the T allele of rs1837253 was significantly associated with a reduced risk of asthma in males only (P = 3 x 10(-6) ). Alternately, the T allele of rs2289276 was significantly associated with a reduced risk of asthma in females only (P = 2 x 10(-4) ). Findings for rs2289276 were consistent in all cohorts except the FHS. CONCLUSIONS: TSLP variants are associated with asthma in a sex-specific fashion.
机译：背景：胸腺基质淋巴细胞生成素（TSLP）中的单核苷酸多态性（SNP）已与IgE（女孩）和哮喘（一般）相关。我们试图确定TSLP SNP是否以性别特异性方式与哮喘相关。方法：我们对哥斯达黎加哮喘患儿家庭中TSLP中SNP与哮喘之间的关联进行了定期和性别分层的分析。在儿童哮喘管理计划的白人和非裔美国人参与者，在非洲人散居研究中的非洲裔美国人哮喘基因组研究，在儿童健康研究中的白人和西班牙裔人以及在弗雷明汉的白人中，发现了重要的发现。心脏研究（FHS）。主要结果：在所有队列的综合分析中，TSLP中的两个SNP（rs1837253和rs2289276）与哮喘风险降低显着相关（P值分别为2 x 10（-5）和1 x 10（-5））。在按性别分层的分析中，仅男性中rs1837253的T等位基因与哮喘风险降低显着相关（P = 3 x 10（-6））。另外，仅在女性中，rs2289276的T等位基因与哮喘风险降低显着相关（P = 2 x 10（-4））。除FHS外，所有人群中rs2289276的发现均一致。结论：TSLP变体以性别特异性方式与哮喘相关。

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