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Anaphylaxis to patent blue V: a case series and proposed diagnostic protocol

机译：专利蓝色V的过敏反应：一个病例系列和建议的诊断方案

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Patent blue V is widely used in the identification of sentinel lymph nodes in patients with breast cancer and other malignancies. Individual case reports of allergy to patent blue V have been described in the medical literature since the 1960s. However, there is little data on clinical features and little experience of which allergy tests are appropriate or useful.We gathered all cases of patent blue V allergy that had been seen and diagnosed in the Department of Allergy, Addenbrooke's Hospital over a 3-year period. We collected clinical details of each case including skin test results. For comparison we recruited 12 healthy control subjects who then underwent skin testing to patent blue V.Six cases of patent blue V allergy were identified, all occurring during sentinel lymph node identification for breast carcinoma. All 6 had positive skin prick tests to neat patent blue V (25 mg/ml). Skin prick testing with a 1 : 10 dilution (2.5 mg/ ml) produced positive results in 3 of 4 patients tested, and intradermal testing at a 1 : 100 dilution was (0.25 mg/ml) was positive in all patients tested. Of 12 control subjects, 11 had negative skin prick tests to both neat and 1 : 10 patent blue V with one subject showing a positive reaction to the higher concentration only.On the basis of our experience of patent blue V allergy, we propose a diagnostic protocol that can be safely and reliably utilised in centres equipped for allergy testing.
机译：专利蓝V被广泛用​​于乳腺癌和其他恶性肿瘤患者前哨淋巴结的鉴定。自1960年代以来，医学文献中已经描述了对漆蓝V过敏的个别病例报告。但是，关于临床特征的数据很少，没有适当或有用的变态反应测试的经验。我们收集了在3年的时间里在阿登布鲁克医院变态反应科中发现并诊断出的所有专利蓝V过敏病例。 。我们收集了每个病例的临床细节，包括皮肤测试结果。为了进行比较，我们招募了12名健康对照受试者，然后对其进行了漆皮蓝V皮肤测试。确定了6例漆皮蓝V过敏病例，所有病例均在乳腺癌前哨淋巴结识别期间发生。所有6名患者的皮肤点刺试验均呈阳性，净纯蓝色V（25 mg / ml）。用1:10稀释液（2.5 mg / ml）进行的皮肤点刺试验在4位接受测试的患者中产生了3例阳性结果，而以1：100稀释度（0.25 mg / ml）进行的皮内测试在所有测试患者中均为阳性。在12名对照受试者中，有11名对纯净和1:10漆皮蓝V的皮肤点刺试验均阴性，其中一名受试者仅对较高浓度的皮肤呈阳性反应。根据我们对漆皮蓝V过敏的经验，我们提出了一种诊断方法可以在配备有过敏测试功能的中心安全，可靠地使用的协议。

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