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首页> 外文期刊>Allergy >HLA DRB1*15-DPB1*05 haplotype: a susceptible gene marker for isocyanate-induced occupational asthma?
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HLA DRB1*15-DPB1*05 haplotype: a susceptible gene marker for isocyanate-induced occupational asthma?

机译：HLA DRB1 * 15-DPB1 * 05单倍型：异氰酸酯诱导的职业性哮喘的易感基因标记？

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Background: There has been no study for evaluating the associations of human leukocyte antigen (HLA) class I and II alleles with toluene diisocyanate (TDI)-induced asthma in an Asian population. Objective: The aim of this study was to investigate a susceptible or protective marker of HLA class I and II alleles in TDI-induced asthma. Methods: Fifty-five patients with TDI-induced asthma patients (group I) showing positive responses on TDI bronchoprovocation test, 47 asymptomatic exposed subjects (group II) and 95 unexposed healthy nonatopic controls (group III) were enrolled in our study. HLA class I and II genotyping was done by the direct DNA sequencing method. Results: The allelic frequency of C*09 (15.5%) was significantly higher in group I than in group III (6.8%, P = 0.019), but this statistical significance disappeared after correction was made for multiple comparisons. On two-locus and three-locus haplotype analysis, the allelic frequency of HLA DRB1*15-DPB1*05 in group I (10.6%) was significantly higher than that of group II (0%, P = 0.001) and group III (2.5%, P = 0.003). The allelic frequencies of HLA A*02-DRB1*15, A*02-DQB1*06, B*62-C*09 and A*02-DRB1*15-DQB1*06 were significantly higher in group I (8.5%, 10.3%, 8.2% and 6.8%, respectively) than those allelic frequencies of group III (1.3%, P = 0.002; 1.6%, P = 0.001; 0.6%, P < 0.0001; 0%, P < 0.0001, respectively). The allelic frequencies of HLA DQB1*06-DPB1*05 and DRB1*15-DQB1*06-DPB1*05 were significantly higher in group I (16.0% and 10.5%) than those in group II (2.5%, P = 0.001; 0%, P = 0.001), while the frequencies of DRB1*09-DPB1*05 and DRB1*09-DQB1*0303-DPB1*05 were significantly lower in group I (0% and 0%) than those of group II (7.4%, P = 0.004; 7.5%, P = 0.004). These differences remained statistically significant even after the correction for multiple comparisons. Conclusions: The HLA haplotype DRB1*15-DPB1*05 can be a susceptibility gene marker for the development of TDI-induced asthma among the exposed workers in the Korean population.
机译：背景：尚无研究评估亚洲人群中人类白细胞抗原（HLA）I和II类等位基因与甲苯二异氰酸酯（TDI）诱发的哮喘的相关性。目的：本研究的目的是研究TDI诱发的哮喘中HLA I和II类等位基因的易感或保护性标志物。方法：55名TDI诱发的哮喘患者（I组）对TDI支气管激发试验呈阳性反应，纳入47名无症状暴露受试者（II组）和95名未暴露健康非过敏性对照（III组）。 HLA I和II类HLA基因分型是通过直接DNA测序方法完成的。结果：C * 09的等位基因频率（15.5％）在第一组比第三组显着更高（6.8％，P = 0.019），但是经过多次比较校正后，这种统计学意义消失了。在两基因座和三基因座单倍型分析中，I组（10.6％）的HLA DRB1 * 15-DPB1 * 05等位基因频率显着高于II组（0％，P = 0.001）和III组（ 2.5％，P = 0.003）。 I组中HLA A * 02-DRB1 * 15，A * 02-DQB1 * 06，B * 62-C * 09和A * 02-DRB1 * 15-DQB1 * 06的等位基因频率显着较高（8.5％，分别比第III组的等位基因频率（分别为1.3％，P = 0.002; 1.6％，P = 0.001; 0.6％，P <0.0001; 0％，P <0.0001）分别高10.3％，8.2％和6.8％）。 I组的HLA DQB1 * 06-DPB1 * 05和DRB1 * 15-DQB1 * 06-DPB1 * 05的等位基因频率显着高于II组（2.5％，P = 0.001; 0％，P = 0.001），而第一组（0％和0％）的DRB1 * 09-DPB1 * 05和DRB1 * 09-DQB1 * 0303-DPB1 * 05的频率显着低于第二组（ 7.4％，P = 0.004; 7.5％，P = 0.004）。即使在进行多次比较校正后，这些差异仍具有统计学意义。结论：HLA单倍型DRB1 * 15-DPB1 * 05可能是韩国人群中TDI诱发的哮喘发展的易感基因标记。

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