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首页> 外文期刊>Allergy >Soluble HLA-G and HLA-A,-B,-C serum levels in patients with allergic rhinitis.
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Soluble HLA-G and HLA-A,-B,-C serum levels in patients with allergic rhinitis.

机译：过敏性鼻炎患者的可溶性HLA-G和HLA-A，-B，-C血清水平。

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摘要

BACKGROUND: Allergic rhinitis (AR) is characterized by Th2-polarized immune response. Soluble HLA (sHLA) molecules play an immunomodulatory activity. So far, however, no study investigated them in AR. OBJECTIVE: The aim of this study was to evaluate sHLA-G and sHLA-A,-B,-C serum levels in AR patients with pollen allergy and in a group of healthy controls. METHODS: Forty-nine AR patients were enrolled. A group of healthy nonallergic subjects was considered as control. sHLA-G and sHLA-A,-B,-C serum levels were determined by immunoenzymatic method. The study was conducted during the winter, such as outside the pollen season. RESULTS: Allergic patients had significantly higher levels of both sHLA-G (P < 0.0001) and sHLA-A,-B,-C (P = 0.011) molecules than normal controls. Moreover, there was a significant relationship between these two soluble molecules (r = 0.69) in allergic patients. CONCLUSION: The present study provides the first evidence that both sHLA-G and sHLA-A,-B,-C serum levels are significantly increased in AR patients with pollen allergy.
机译：背景：过敏性鼻炎（AR）的特征是Th2极化的免疫反应。可溶性HLA（sHLA）分子具有免疫调节活性。但是，到目前为止，尚无研究在AR中对其进行研究。目的：本研究旨在评估花粉过敏的AR患者和一组健康对照者的sHLA-G和sHLA-A，-B，-C血清水平。方法：49例AR患者入选。一组健康的非过敏性受试者被视为对照组。 sHLA-G和sHLA-A，-B，-C血清水平通过免疫酶法测定。该研究在冬季进行，例如在花粉季节之外。结果：变态反应患者的sHLA-G（P <0.0001）和sHLA-A，-B，-C（P = 0.011）分子水平均显着高于正常对照组。此外，在过敏患者中，这两个可溶性分子之间存在显着关系（r = 0.69）。结论：本研究提供了第一个证据，表明花粉过敏的AR患者的sHLA-G和sHLA-A，-B，-C血清水平均显着升高。

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