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首页> 外文期刊>Allergy >IL-10 promoter and IL4-Ralpha gene SNPs are associated with immediate beta-lactam allergy in atopic women.
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IL-10 promoter and IL4-Ralpha gene SNPs are associated with immediate beta-lactam allergy in atopic women.

机译：IL-10启动子和IL4-Ralpha基因SNP与特应性女性立即β-内酰胺过敏相关。

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BACKGROUND: Allergic reactions to beta-lactam antibiotics represent the most frequent cause of immunological drug reactions. OBJECTIVE: This study evaluates the involvement of genetic susceptibility factors in patients with immediate allergic reactions to beta-lactams. We examined 15 single nucleotide polymorphisms (SNP) of genes coding proteins implicated in immunoglobulin (Ig)E synthesis regulation. METHODS: We performed a case-control study involving 44 patients with immediate beta-lactam allergy and 44 control subjects, all matched for sex and atopy. Interleukin (IL)-4, IL-13, IL-4Ralpha, signal transducer and activator of transcription 6 (STAT6), interferon (IFN)-gammaR1, IFN-gammaR2 and FcepsilonRIbeta gene polymorphisms were determined using polymerase chain reaction (PCR) restriction fragment length polymorphism, and IL-21R gene and IL-10 promoter polymorphisms by direct sequencing. RESULTS: Our analysis did not reveal differences in the distribution of the 15 SNPs between allergic patients andcontrols. However, among atopic subjects, we found two distinct significant associations between immediate beta-lactam allergy in women and the Ile75Val variant of IL-4Ralpha gene (P = 0.012, OR = 5.4, CI: 1.16-27.7), and two linked IL-10 promoter gene polymorphisms, -819C>T and -592 C>A (P = 0.023, OR = 17.5, CI: 1.26-533.07). In contrast, we observed no association in allergic male subjects in the atopic population. Interestingly, the IL-4Ralpha Ile75Val variant could have a paradoxal protective effect in atopic male patients (P = 0.004, OR = 0.07, CI: 0.01-0.66). CONCLUSION: Our findings suggest that polymorphisms in the IL-10 promoter and IL-4Ralpha genes are genetic factors that favour beta-lactam immediate allergies in female patients with atopy.
机译：背景：对β-内酰胺类抗生素的过敏反应是免疫药物反应的最常见原因。目的：本研究评估了对β-内酰胺类直接过敏反应的患者中遗传易感因素的参与。我们检查了编码免疫球蛋白（Ig）E合成调节牵连的蛋白质的基因的15个单核苷酸多态性（SNP）。方法：我们进行了一项病例对照研究，涉及44例立即有β-内酰胺过敏症的患者和44例对照受试者，所有受试者均符合性别和特应性。白细胞介素（IL）-4，IL-13，IL-4Ralpha，信号转导和转录激活因子6（STAT6），干扰素（IFN）-gammaR1，IFN-gammaR2和FcepsilonRIbeta基因多态性使用聚合酶链反应（PCR）限制进行测定片段长度多态性，以及IL-21R基因和IL-10启动子多态性通过直接测序。结果：我们的分析未发现过敏患者与对照组之间15个SNP的分布存在差异。但是，在特应性受试者中，我们发现女性的直接β-内酰胺过敏与IL-4Ralpha基因的Ile75Val变体之间存在两个明显的显着关联（P = 0.012，OR = 5.4，CI：1.16-27.7），以及两个相关的IL- 10个启动子基因多态性，-819C> T和-592C> A（P = 0.023，OR = 17.5，CI：1.26-533.07）。相比之下，我们在特应性人群中未观察到过敏性男性受试者的关联。有趣的是，IL-4Ralpha Ile75Val变异体在特应性男性患者中可能具有悖论的保护作用（P = 0.004，OR = 0.07，CI：0.01-0.66）。结论：我们的研究结果表明，IL-10启动子和IL-4Ralpha基因的多态性是遗传因素，有利于女性特应性患者发生β-内酰胺立即过敏。

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