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首页> 外文期刊>Allergy >Seasonal dynamics of chemokine receptors and CD62L in subjects with asymptomatic skin sensitization to birch and grass pollen.
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Seasonal dynamics of chemokine receptors and CD62L in subjects with asymptomatic skin sensitization to birch and grass pollen.

机译：对桦木和花粉无症状皮肤过敏的受试者中趋化因子受体和CD62L的季节性变化。

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Background: Asymptomatic skin sensitization (AS) has been shown to be a risk factor for respiratory allergic disease. CCR4, CXCR1 and CD62L have all been assigned a role in the immunopathogenesis of allergy. Memory T-cell expression of CCR4, CXCR1 and CD62L has not hitherto been investigated in subjects with AS. Methods: We investigated seasonal CD4 memory T-cell expression of the chemokine receptors CCR4, CXCR1 as well as L-selectin (CD62L) in fresh cultures derived from symptomatic atopics (SAs), subjects with AS and healthy controls (HCs). Peripheral blood mononuclear cells from all three groups were isolated during birch and grass pollination as well as in the following winter. CD4 memory T-cell expression of CCR4, CXCR1 and CD62L was determined by flow-cytometry. Results: During spring and summer, a significantly increased proportion of memory T cells expressed CCR4, CXCR1 and CD62L in SAs when compared with subjects with AS and HCs. Only SAs exhibited seasonal fluctuations in numbers of CCR4, CXCR1 and CD62L positive memory T cells. Conclusion: Although clearly IgE sensitized, subjects with AS have significant diminished numbers of CCR4, CXCR1 and CD62L positive memory T cells, during pollination, when compared with SAs. In contrast to SAs, cultures derived from subjects with AS did not display seasonal variation. Our findings explain the lack of clinical symptoms, during pollination, in subjects with AS.
机译：背景：无症状皮肤致敏（AS）已被证明是呼吸道过敏性疾病的危险因素。 CCR4，CXCR1和CD62L在过敏的免疫发病机理中均被赋予了作用。迄今为止，尚未在患有AS的受试者中研究CCR4，CXCR1和CD62L的记忆T细胞表达。方法：我们调查了来自有症状异位性变应症（SAs），AS受试者和健康对照（HCs）的新鲜培养物中趋化因子受体CCR4，CXCR1和L-选择素（CD62L）的季节性CD4记忆T细胞表达。在桦树和草粉授粉期间以及接下来的冬季中，从三组中分离出外周血单个核细胞。通过流式细胞术确定CCR4，CXCR1和CD62L的CD4记忆T细胞表达。结果：在春季和夏季，与患有AS和HC的受试者相比，在SA中表达CCR4，CXCR1和CD62L的记忆T细胞比例显着增加。仅SA显示出CCR4，CXCR1和CD62L阳性记忆T细胞数量的季节性波动。结论：尽管与SAs相比，AS受试者在授粉期间具有明显的IgE敏感性，但在授粉过程中CCR4，CXCR1和CD62L阳性记忆T细胞的数量明显减少。与SA相比，来自AS受试者的培养物没有季节性变化。我们的发现解释了AS受试者在授粉期间缺乏临床症状。

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