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Menopausal asthma: a new biological phenotype?

机译：更年期哮喘：一种新的生物学表型？

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BACKGROUND: Female hormones play an important role in women's lung health, especially in asthma pathophysiology. Although a growing interest has recently been aroused in asthma related to short-term reproductive states, menopausal asthma has been little studied in the past. The aim of the present study was to explore airway inflammation in menopausal asthmatic women in a noninvasive manner. METHODS: Forty consecutive women with menopausal asthma, 35 consecutive women with premenopausal asthma and 30 age-matched healthy controls were enrolled in the study. Urinary LTE-4, induced sputum inflammatory cells, and exhaled LTE-4, IL-6, pH, and NO levels were measured in all the subjects enrolled. RESULTS: Women with menopausal asthma showed decreased estradiol concentrations, high sputum neutrophils, and exhaled IL-6. Women with premenopausal asthma presented instead an essentially eosinophilic inflammatory pattern. Higher urine and breath condensate LTE-4 concentrations were found in premenopausal and menopausal asthma compared to controls. CONCLUSION: Our results substantiate the existence of a new biological phenotype of menopausal asthma that is mainly characterized by neutrophilic airways inflammation and shares several characteristics of the severe asthma phenotype.
机译：背景：女性激素在女性肺部健康，尤其是哮喘病理生理中起着重要作用。尽管最近引起了对与短期生殖状态有关的哮喘的越来越多的兴趣，但过去绝经期哮喘的研究很少。本研究的目的是以无创方式探讨更年期哮喘妇女的气道炎症。方法：本研究纳入了40例连续的绝经期哮喘妇女，35例连续的绝经前哮喘妇女和30位年龄匹配的健康对照者。在所有入组受试者中均测量了尿液LTE-4，诱导的痰​​炎症细胞以及呼出的LTE-4，IL-6，pH和NO水平。结果：绝经期哮喘妇女表现出雌二醇浓度降低，痰中性粒细胞增高和呼出的IL-6。绝经前哮喘的妇女表现出一种本质上嗜酸性的炎症模式。与对照组相比，绝经前和绝经期哮喘患者的尿液和呼吸道冷凝物LTE-4浓度更高。结论：我们的结果证实了绝经期哮喘的一种新的生物表型的存在，其主要特征是嗜中性气道炎症并具有严重哮喘表型的几个特征。

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