• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Allergy >Filaggrin gene mutations are associated with independent atopic asthma in Chinese patients.
【24h】

Filaggrin gene mutations are associated with independent atopic asthma in Chinese patients.

机译：丝聚蛋白基因突变与中国患者的独立性特应性哮喘有关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Asthma is a complex disease manifesting as two major phenotypes, namely nona-topic and atopic asthma (AA). AA is the most common form, particularly in preschool children. On the basis of two meta-analyses, it was concluded that no association exists between FLG mutations and asthma without the coexistence of atopic dermatitis (AD) (1,2). However, Poninska et al. (3) reported that filaggrin gene {FLG) defects were significantly associated with AA without the coexistence of AD in a Polish population. Through a previous study conducted by our group, we recently confirmed that FLG defects are significantly associated with asthma combined with AD in Chinese patients (4). Nevertheless, the extent to which this association is present in AD-free AA patients in China is unclear. In the current study, 121 A A patients without AD were examined using an overlapping PCR strategy.
机译：哮喘是一种复杂的疾病，表现为两种主要表型，即九型哮喘和特应性哮喘（AA）。 AA是最常见的形式，尤其是在学龄前儿童中。根据两项荟萃分析，得出的结论是，如果没有特应性皮炎（AD）并存，则FLG突变与哮喘之间不存在关联（1,2）。但是，Poninska等。 （3）报告说，波兰人群中丝蛋白基因（FLG）缺陷与AA显着相关，而AD没有并存。通过我们小组先前的研究，我们最近证实，中国患者的FLG缺陷与哮喘合并AD密切相关（4）。然而，目前尚不清楚在中国无AD的AA患者中这种关联的程度。在本研究中，使用重叠PCR策略检查了121名无AD的AA患者。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号