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Risk of asthma in adult twins with type 2 diabetes and increased body mass index.

机译：成年双胞胎患有2型糖尿病和体重指数增加的哮喘风险。

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AIM: To examine the relationship between asthma, type 2 diabetes and increased body mass index (BMI) in adult twins. METHODS: We performed record linkage between questionnaire-defined asthma and BMI, and hospital discharge diagnoses of type 2 diabetes in 34,782 Danish twins, 20-71 years of age. RESULTS: The risk of asthma was increased in subjects with type 2 diabetes relative to nondiabetic subjects both in men (13.5%vs 7.5%), P = 0.001 and in women (16.6%vs 9.6%), P = 0.001. The result remained significant after adjustment for age, BMI, smoking, symptoms of chronic bronchitis, marital status and zygosity, men: OR = 1.70 (1.07-2.70), P = 0.026; women: OR = 1.88 (1.24-2.85), P = 0.003. In this analysis, BMI remained a highly significant predictor for asthma independently of diabetes status in women, P < 0.000 but not in men, P = 0.336. Significant positive genetic correlations were found between asthma and type 2 diabetes, 0.20 (0.01-0.40), P = 0.047; between asthma and BMI in women, 0.15 (0.07-0.22), P < 0.000; and between BMI and type 2 diabetes, 0.40 (0.29-0.43), P < 0.000. CONCLUSIONS: Asthma, type 2 diabetes and increased BMI are strongly associated in adults, particularly in women. These results suggest a common aetiology for asthma and metabolic syndrome.
机译：目的：探讨成年双胞胎中哮喘，2型糖尿病与体重指数（BMI）增加之间的关系。方法：我们对34782名20-71岁的丹麦双胞胎进行了问卷调查定义的哮喘和BMI与医院出院2型糖尿病诊断之间的记录联系。结果：相对于非糖尿病患者，男性（13.5％vs 7.5％）和女性（16.6％vs 9.6％）（P = 0.001）相对于非糖尿病患者，哮喘风险增加。在调整了年龄，BMI，吸烟，慢性支气管炎的症状，婚姻状况和接合性之后，结果仍然很明显，男性：OR = 1.70（1.07-2.70），P = 0.026;女性：OR = 1.88（1.24-2.85），P = 0.003。在此分析中，女性的BMI仍然是哮喘的高度重要预测指标，与糖尿病状态无关，P <0.000，而男性则没有，P = 0.336。发现哮喘与2型糖尿病之间存在显着的正相关性，为0.20（0.01-0.40），P = 0.047;女性哮喘与BMI之间的关系为0.15（0.07-0.22），P <0.000;在BMI和2型糖尿病之间，为0.40（0.29-0.43），P <0.000。结论：哮喘，2型糖尿病和BMI升高与成年人特别是女性密切相关。这些结果提示哮喘和代谢综合征的常见病因。

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