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首页> 外文期刊>Allergy >Factors responsible for differences between asymptomatic subjects and patients presenting an IgE sensitization to allergens. A GALEN project.
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Factors responsible for differences between asymptomatic subjects and patients presenting an IgE sensitization to allergens. A GALEN project.

机译：导致无症状受试者与对过敏原呈IgE致敏的患者之间差异的因素。一个GALEN项目。

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摘要

The synthesis of allergen-specific IgE is required for the development of allergic diseases including allergic rhinitis and allergic asthma (patients), but many individuals with allergen-specific IgE do not develop symptoms (asymptomatic subjects). Differences may exist between asymptomatic subjects and patients. Whether the presence of allergen-specific IgE translates into clinical allergy most likely depends on a complex interplay of multiple factors. These include a family history of atopy, the levels of total serum IgE and, allergen-specific IgE or IgG, epitope-specificity of IgE and their degree of polyclonality (mono- vs polysensitized), as yet unidentified serum factors, the balance of T regulatory cells (Treg) and Th1/Th2 cells, the polymorphisms of the high affinity receptor for IgE (FcepsilonRI) and other factors regulating the activation of FcepsilonRI-bearing cells. Asymptomatic subjects may be more often monosensitized than patients who may be more often polysensitized. There are many unanswered important questions that need to be addressed in order to better understand how IgE sensitization translates into clinical allergy. The assessment of differences between the asymptomatic and symptomatic groups of subjects represent one of the scientific programs of Global Allergy and Asthma European Network funded by the European Union and the hypotheses underlying these differences are presented in this paper.
机译：包括变应性鼻炎和变应性哮喘在内的变应性疾病的发展需要合成变应原特异性IgE（患者），但是许多患有变应原特异性IgE的人不会出现症状（无症状受试者）。无症状受试者和患者之间可能存在差异。过敏原特异性IgE的存在是否最有可能转化为临床过敏，取决于多种因素的复杂相互作用。这些包括特应性家族病史，总血清IgE和过敏原特异性IgE或IgG的水平，IgE的表位特异性及其多克隆程度（单敏或多敏），尚未确定的血清因素，T平衡调节细胞（Treg）和Th1 / Th2细胞，对IgE的高亲和力受体（FcepsilonRI）的多态性和其他调节FcepsilonRI承载细胞活化的因素。与可能更经常多敏感的患者相比，无症状受试者可能更常被单敏。为了更好地了解IgE致敏如何转化为临床过敏，有许多悬而未决的重要问题需要解决。无症状和症状组之间差异的评估是欧盟资助的全球过敏和哮喘欧洲网络的一项科学计划，本文提出了这些差异的基础假设。

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