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Towards global consensus on outcome measures for atopic eczema research: Results of the HOME II meeting

机译：达成就特应性湿疹研究的结局指标达成全球共识：HOME II会议的结果

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The use of nonstandardized and inadequately validated outcome measures in atopic eczema trials is a major obstacle to practising evidence-based dermatology. The Harmonising Outcome Measures for Eczema (HOME) initiative is an international multiprofessional group dedicated to atopic eczema outcomes research. In June 2011, the HOME initiative conducted a consensus study involving 43 individuals from 10 countries, representing different stakeholders (patients, clinicians, methodologists, pharmaceutical industry) to determine core outcome domains for atopic eczema trials, to define quality criteria for atopic eczema outcome measures and to prioritize topics for atopic eczema outcomes research. Delegates were given evidence-based information, followed by structured group discussion and anonymous consensus voting. Consensus was achieved to include clinical signs, symptoms, long-term control of flares and quality of life into the core set of outcome domains for atopic eczema trials. The HOME initiative strongly recommends including and reporting these core outcome domains as primary or secondary endpoints in all future atopic eczema trials. Measures of these core outcome domains need to be valid, sensitive to change and feasible. Prioritized topics of the HOME initiative are the identification/development of the most appropriate instruments for the four core outcome domains. HOME is open to anyone with an interest in atopic eczema outcomes research.
机译：在特应性湿疹试验中使用未标准化且未经充分验证的结局指标是实践循证皮肤病学的主要障碍。协调湿疹的预后指标（HOME）计划是一个致力于异位性湿疹预后研究的国际性多专业小组。 2011年6月，HOME计划进行了一项共识研究，涉及来自10个国家的43位代表不同利益相关者（患者，临床医生，方法学家，制药行业）的人员，以确定特应性湿疹试验的核心结果域，从而确定特应性湿疹结果测量的质量标准并优先进行特应性湿疹结果研究的主题。向代表们提供了基于证据的信息，然后进行了结构化的小组讨论和匿名共识投票。达成共识，将临床症状，症状，耀斑的长期控制和生活质量纳入特应性湿疹试验的主要结局领域。 HOME倡议强烈建议在所有未来的特应性湿疹试验中将这些核心结果域包括在内并报告为主要终点或次要终点。这些核心成果领域的措施必须有效，对变化敏感并且可行。 HOME计划的优先主题是为四个核心成果领域确定/开发最合适的工具。 HOME向对特应性湿疹结果研究感兴趣的任何人开放。

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