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首页> 外文期刊>Allergy >X-chromosome Forkhead Box P3 polymorphisms associate with atopy in girls in three Dutch birth cohorts.
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X-chromosome Forkhead Box P3 polymorphisms associate with atopy in girls in three Dutch birth cohorts.

机译：X染色体叉头盒P3多态性与三个荷兰出生队列中女孩的特应性相关。

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BACKGROUND: The Forkhead Box P3 (FOXP3) gene, located on the X-chromosome, encodes a transcription factor that directs T cells toward a regulatory phenotype. Regulatory T cells may suppress development of atopy. We evaluated whether single-nucleotide polymorphisms (SNPs) of FOXP3 are associated with atopy development in childhood. METHODS: Seven SNPs in FOXP3 were genotyped in 3062 children (51% boys) participating in the Allergenic study, which consists of three Dutch birth cohorts (PIAMA, PREVASC and KOALA). Association of FOXP3 SNPs with total serum IgE and sensitisation (presence of specific serum IgE to egg, milk, and indoor, i.e. house-dust mite, cat, and/or dog allergens) was investigated at ages 1, 2, 4, and 8. Analysis of variance and logistic regression were performed, stratified for gender. RESULTS: Our most consistent finding was observed for sensitisation to egg and indoor allergens. In girls, five FOXP3 SNPs (rs5906761, rs2294021, rs2294019, rs6609857 and rs3761548) were significantly associated with sensitisation to egg at ages 1 and 2 and with sensitisation to indoor allergens at age 2 (P < 0.05), but not at 4 and 8, a finding that was observed across the three cohorts. Rs5906761 and rs2294021 were associated with remission of sensitisation to food allergens in boys, as tested in the PIAMA cohort. CONCLUSION: This is the first study showing across three cohorts that X-chromosomal FOXP3 genotypes may contribute to development of sensitisation against egg and indoor allergens in girls in early childhood. In addition, an association with remission of sensitisation to food allergens existed in boys only.
机译：背景：位于X染色体上的Forkhead Box P3（FOXP3）基因编码一种转录因子，该因子指导T细胞趋向调节表型。调节性T细胞可以抑制特应性的发展。我们评估了FOXP3的单核苷酸多态性（SNP）是否与童年的特应性发育有关。方法：在参与变应原研究的3062名儿童（51％的男孩）中对FOXP3中的7个SNP进行了基因分型，该研究由3个荷兰出生队列（PIAMA，PREVASC和KOALA）组成。在1、2、4和8岁分别研究了FOXP3 SNP与总血清IgE和致敏性（鸡蛋，牛奶和室内即屋尘螨，猫和/或狗过敏原的特异性血清IgE的存在）之间的关系。进行方差分析和逻辑回归，按性别分层。结果：我们最一致的发现是对鸡蛋和室内变应原致敏。在女孩中，五个FOXP3 SNP（rs5906761，rs2294021，rs2294019，rs6609857和rs3761548）与1和2岁时对鸡蛋的致敏性以及2岁时对室内变应原的致敏性显着相关（P <0.05），而在4和8岁时则不相关。 ，这是在三个队列中观察到的发现。根据PIAMA队列测试，Rs5906761和rs2294021与男孩对食物过敏原的敏感性降低相关。结论：这是第一项跨三个队列研究，表明X染色体FOXP3基因型可能有助于幼儿期对蛋和室内变应原的致敏性发展。另外，仅男孩中存在与食物过敏原敏感性降低有关的关联。

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