...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Allergy >Towards evidence-based medicine in specific grass pollen immunotherapy
【24h】

Towards evidence-based medicine in specific grass pollen immunotherapy

机译：在特定的草花粉免疫疗法中寻求循证医学

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

When initiating grass pollen immunotherapy for seasonal allergic rhinoconjunctivi-tis, specialist physicians in many European countries must choose between modalities of differing pharmaceutical and regulatory status. We applied an evidence-based medicine (EBM) approach to commercially available subcutaneous and sublingual Gramineae grass pollen immunotherapies (SCIT and SLIT) by evaluating study design, populations, pollen seasons, treatment doses and durations, efficacy, quality of life, safety and compliance. After searching MEDLINE, Embase and the Cochra-ne Library up until January 2009, we identified 33 randomized, double-blind, placebo-controlled trials (including seven paediatric trials) with a total of 440 specific immunotherapy (SIT)-treated subjects in seven trials (0 paediatric) for SCIT with natural pollen extracts, 168 in three trials (0 paediatric) for SCIT with allergoids, 906 in 16 trials (five paediatric) for natural extract SLIT drops, 41 in two trials (one paediatric) for allergoid SLIT tablets and 1605 in five trials (two paediatric) for natural extract SLIT tablets. Trial design and quality varied significantly within and between SIT modalities. The multinational, rigorous trials of natural extract SLIT tablets correspond to a high level of evidence in adult and paediatric populations. The limited amount of published data on allergoids prevented us from judging the level of evidence for this modality.
机译：在开始针对季节性变应性鼻结膜炎的草花粉免疫治疗时，许多欧洲国家的专科医生必须在药物和监管状况不同的方式之间进行选择。我们通过评估研究设计，人群，花粉季节，治疗剂量和持续时间，疗效，生活质量，安全性和依从性，将循证医学（EBM）方法应用于市售的皮下和舌下禾本科草花粉免疫疗法（SCIT和SLIT） 。在搜寻MEDLINE，Embase和Cochra-ne图书馆之前，直到2009年1月，我们确定了33项随机，双盲，安慰剂对照试验（包括7项儿科试验），其中有440例经特定免疫疗法（SIT）治疗的受试者天然花粉提取物的SCIT试验（0个儿科），变应性动物SCIT的三个试验（0个儿科），天然提取物SLIT滴剂的16个试验（5个儿科）906个试验，变应性SLIT的两个试验（1个儿科）天然提取物SLIT片剂的五项试验（两项儿科）中有1605粒和1605粒。在SIT模式内部和之间，试验设计和质量有很大差异。天然提取物SLIT片剂的多国严格试验对应于成人和儿童人群的高水平证据。有关变态反应动物的公开数据数量有限，使我们无法判断这种方法的证据水平。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号