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Endothelial L-selectin ligand expression in nasal polyps.

机译：鼻息肉中的内皮L-选择素配体表达。

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BACKGROUND: L-selectins on leukocytes and their counter-receptors on endothelial cells have been shown to be involved in leukocyte recruitment in chronic rhinosinusitis without nasal polyps (NP). OBJECTIVES: The purpose of this study was to evaluate the expression level of functionally active endothelial L-selectin ligands in NP obtained from patients with NP of different etiology [simple NP, antro-choanal polyps (ACP) and cystic fibrosis (CF) NP] and inferior turbinate specimens of healthy controls and to compare these levels to the presence of various leukocyte subsets. METHODS: Nasal polyp specimens and healthy nasal mucosa specimens were obtained from patients undergoing surgery and were immunohistochemically stained with monoclonal antibodies detecting CD34, sialyl Lewis x (sLe(x)) of sulfated extended core 1 lactosamines and various leukocyte subsets. RESULTS: All NP are characterized by a decrease in the number of CD34+ vessels. The number of eosinophils and the percentage of vessels expressing endothelial sulfated sLe(x) epitopes is upregulated in all groups of simple NP. Tissue eosinophilia is increased in those patients with increased disease severity (acetyl salicylic acid intolerance), but the percentage of endothelial sulfated sLe(x) epitopes is not. Results on CF NP are similar to those observed for simple NP. Antro-choanal polyps, on the contrary, are characterized by low numbers of tissue eosinophils and relatively few vessels expressing endothelial sulfated sLe(x) epitopes. CONCLUSIONS: Our results suggest that functionally active L-selectin ligands might play a role in guiding leukocyte traffic into NP in patients with simple NP and CF NP but not ACP.
机译：背景：在没有鼻息肉（NP）的慢性鼻-鼻窦炎中，白细胞上的L选择素及其内皮细胞的反受体已被证明参与白细胞募集。目的：本研究的目的是评估功能不同的内皮源性L-选择蛋白配体在不同病因的NP患者中的表达水平[简单NP，肛管息肉（ACP）和囊性纤维化（CF）NP]以及健康对照者的下鼻甲标本，并将这些水平与各种白细胞亚群的存在进行比较。方法：鼻息肉标本和健康的鼻黏膜标本取自接受手术的患者，并用单克隆抗体进行免疫组织化学染色，检测CD34，唾液酸化路易斯1（sLe（x）），硫酸化延伸核心1乳糖胺和各种白细胞亚群。结果：所有NP的特征在于CD34 +血管数目的减少。在所有简单NP组中，嗜酸性粒细胞的数量和表达内皮硫酸化的sLe（x）表位的血管的百分比上调。在疾病严重程度增加（乙酰水杨酸不耐受）的患者中，组织嗜酸性粒细胞增多，但内皮硫酸化的sLe（x）表位的百分比却没有。 CF NP的结果类似于简单NP的结果。相反，前额鼻息肉的特征是组织嗜酸性粒细胞少，表达内皮硫酸化的sLe（x）表位的血管相对较少。结论：我们的结果表明，功能性L-选择蛋白配体可能在指导单纯性NP和CF NP而非ACP的患者中引导白细胞进入NP中。

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